Kawada T, Tohyama C, Suzuki S
Department of Public Health, Gunma University School of Medicine, Maebashi-shi, Japan.
Asia Pac J Public Health. 1995;8(2):91-4. doi: 10.1177/101053959500800206.
Cadmium (Cd), lead (Pb), N-acetyl-beta-D-glucosaminidase (NAG), beta 2-microglobulin (BMG), metallothionein (MT) and creatinine (cre) in urine were measured in 36 male workers. Urinary Cd and Pb ranged from 0.2 to 9.7 and 0.1 to 4.8 micrograms/g cre with geometric means of 1.17 and 1.27 micrograms/g cre, respectively. Partial correlation coefficients between the logarithm of urinary Cd and that of NAG, BMG or MT controlling for pH and age were 0.460 (p < 0.01), 0.095 and 0.677 (p < 0.01), respectively. Partial correlation coefficients between the logarithm of Pb and that of NAG, BMG or MT controlling for pH and age were 0.040, 0.403 (p < 0.05) and -0.183, respectively. Multiple regression analysis was conducted on urinary NAG, BMG and MT using age, pH, log U-Cd and U-Pb. Log U-Cd was the only significant predictor variable of NAG (beta = 0.572; p < 0.01). Log U-Pb was the only predictor variable of BMG (beta = 0.386, p < 0.01). pH (beta = 0.286, p < 0.05) and Log U-Cd (beta = 0.839, p < 0.05) were significant predictor variables of MT.
对36名男性工人的尿液中的镉（Cd）、铅（Pb）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、β2-微球蛋白（BMG）、金属硫蛋白（MT）和肌酐（cre）进行了测量。尿镉和尿铅的范围分别为0.2至9.7微克/克肌酐和0.1至4.8微克/克肌酐，几何平均值分别为1.17和1.27微克/克肌酐。在控制pH值和年龄的情况下，尿镉对数与NAG、BMG或MT对数之间的偏相关系数分别为0.460（p<0.01）、0.095和0.677（p<0.01）。在控制pH值和年龄的情况下，铅对数与NAG、BMG或MT对数之间的偏相关系数分别为0.040、0.403（p<0.05）和-0.183。使用年龄、pH值、尿镉对数（log U-Cd）和尿铅（U-Pb）对尿NAG、BMG和MT进行多元回归分析。log U-Cd是NAG的唯一显著预测变量（β=0.572；p<0.01）。log U-Pb是BMG的唯一预测变量（β=0.386，p<0.01）。pH值（β=0.286，p<0.05）和log U-Cd（β=0.839，p<0.05）是MT的显著预测变量。
