Jepson A, Banya W, Sisay-Joof F, Hassan-King M, Nunes C, Bennett S, Whittle H
MRC Laboratories, Fajara, The Gambia.
Infect Immun. 1997 Mar;65(3):872-6. doi: 10.1128/IAI.65.3.872-876.1997.
Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gambian twins we report that regulation of the immune response to a variety of antigens from Plasmodium falciparum and Mycobacterium tuberculosis is controlled by factors which are encoded by genes that lie both within and outside the major histocompatibility complex (MHC). We define the relative contribution of these genes, which varies for different antigens. The cumulative genetic contribution of non-MHC genes to the total phenotypic variance exceeds that of the MHC-encoded genes.
了解遗传因素对免疫反应的影响程度对于亚单位疫苗的研发至关重要。与人类白细胞抗原（HLA）基因多态性的关联似乎不足以解释对疫苗以及主要病原体感染的免疫反应变化范围。在这项针对冈比亚双胞胎的研究中，我们报告称，对来自恶性疟原虫和结核分枝杆菌的多种抗原的免疫反应调控由主要组织相容性复合体（MHC）内外的基因所编码的因素控制。我们确定了这些基因的相对贡献，其因不同抗原而异。非MHC基因对总表型变异的累积遗传贡献超过了MHC编码基因的贡献。
