主要组织相容性复合体（MHC）和非MHC基因对人类对外源抗原免疫反应的相对贡献的量化。
Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.
作者信息
Jepson A, Banya W, Sisay-Joof F, Hassan-King M, Nunes C, Bennett S, Whittle H
机构信息
MRC Laboratories, Fajara, The Gambia.
出版信息
Infect Immun. 1997 Mar;65(3):872-6. doi: 10.1128/IAI.65.3.872-876.1997.
Abstract
Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gambian twins we report that regulation of the immune response to a variety of antigens from Plasmodium falciparum and Mycobacterium tuberculosis is controlled by factors which are encoded by genes that lie both within and outside the major histocompatibility complex (MHC). We define the relative contribution of these genes, which varies for different antigens. The cumulative genetic contribution of non-MHC genes to the total phenotypic variance exceeds that of the MHC-encoded genes.
摘要
了解遗传因素对免疫反应的影响程度对于亚单位疫苗的研发至关重要。与人类白细胞抗原（HLA）基因多态性的关联似乎不足以解释对疫苗以及主要病原体感染的免疫反应变化范围。在这项针对冈比亚双胞胎的研究中，我们报告称，对来自恶性疟原虫和结核分枝杆菌的多种抗原的免疫反应调控由主要组织相容性复合体（MHC）内外的基因所编码的因素控制。我们确定了这些基因的相对贡献，其因不同抗原而异。非MHC基因对总表型变异的累积遗传贡献超过了MHC编码基因的贡献。
相似文献
1
Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.主要组织相容性复合体（MHC）和非MHC基因对人类对外源抗原免疫反应的相对贡献的量化。
Infect Immun. 1997 Mar;65(3):872-6. doi: 10.1128/IAI.65.3.872-876.1997.
2
14th International HLA and Immunogenetics Workshop: report on joint study on MHC and infection.第十四届国际人类白细胞抗原与免疫遗传学研讨会：关于主要组织相容性复合体与感染联合研究的报告
Tissue Antigens. 2007 Apr;69 Suppl 1:226-7. doi: 10.1111/j.1399-0039.2006.773_1.x.
3
Failure to detect MHC class II associations of the human immune response induced by repeated malaria infections to the Plasmodium falciparum antigen Pf155/RESA.未能检测到由反复疟疾感染引发的针对恶性疟原虫抗原Pf155/RESA的人类免疫反应与MHC II类分子的关联。
Int Immunol. 1991 Oct;3(10):1043-51. doi: 10.1093/intimm/3.10.1043.
4
The role of MHC- and non-MHC-associated genes in determining the human immune response to malaria antigens.MHC相关基因和非MHC相关基因在决定人类对疟疾抗原免疫反应中的作用。
Parasitology. 1996;112 Suppl:S39-51.
5
Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.主要组织相容性复合体II类基因表达的分子特征及抗原特异性T细胞反应的证实表明II类缺陷患者存在一种新的表型。
J Exp Med. 1995 Apr 1;181(4):1411-23. doi: 10.1084/jem.181.4.1411.
6
Human leukocyte antigen class II control of the immune response to p126-derived amino terminal peptide from Plasmodium falciparum.人类白细胞抗原II类对恶性疟原虫p126衍生氨基末端肽免疫反应的控制。
Am J Trop Med Hyg. 2002 May;66(5):509-15. doi: 10.4269/ajtmh.2002.66.509.
7
8
Cellular and humoral immune responses to Plasmodium falciparum gametocyte antigens in malaria-immune individuals. Limited response to the 48/45-kilodalton surface antigen does not appear to be due to MHC restriction.疟疾免疫个体对恶性疟原虫配子体抗原的细胞免疫和体液免疫反应。对48/45千道尔顿表面抗原的反应有限，这似乎并非由于主要组织相容性复合体（MHC）限制所致。
J Immunol. 1990 Jun 15;144(12):4810-6.
9
1987 Philip Levine award lecture. MHC haplotypes in biology and medicine.1987年菲利普·莱文奖讲座。生物学和医学中的主要组织相容性复合体单倍型
Am J Clin Pathol. 1988 Feb;89(2):268-80. doi: 10.1093/ajcp/89.2.268.
10
Malaria antigens and MHC restriction.疟疾抗原与主要组织相容性复合体限制
Immunol Lett. 1990 Aug;25(1-3):265-70. doi: 10.1016/0165-2478(90)90125-a.
引用本文的文献
1
Understanding Heritable Variation Among Hosts in Infectious Diseases Through the Lens of Twin Studies.通过双胞胎研究视角理解传染病宿主间的遗传变异
Genes (Basel). 2025 Feb 1;16(2):177. doi: 10.3390/genes16020177.
2
Cytokine gene polymorphism and parasite susceptibility in free-living rodents: Importance of non-coding variants.细胞因子基因多态性与自由生活啮齿动物寄生虫易感性：非编码变异的重要性。
PLoS One. 2023 Jan 24;18(1):e0258009. doi: 10.1371/journal.pone.0258009. eCollection 2023.
3
Molecular Characterization of MHC Class I Genes in Four Species of the Family to Assess Genetic Diversity and Selection.评估四种鲇科鱼类遗传多样性和选择的MHC I类基因的分子特征分析
Biomed Res Int. 2021 Apr 10;2021:5585687. doi: 10.1155/2021/5585687. eCollection 2021.
4
Genetic influences on viral-induced cytokine responses in the lung.遗传对肺部病毒诱导细胞因子反应的影响。
Mucosal Immunol. 2021 Jan;14(1):14-25. doi: 10.1038/s41385-020-00355-6. Epub 2020 Nov 12.
5
Nucleotide diversity of functionally different groups of immune response genes in Old World camels based on newly annotated and reference-guided assemblies.基于新注释和参考指导组装的旧世界骆驼不同功能免疫反应基因群体的核苷酸多样性。
BMC Genomics. 2020 Sep 3;21(1):606. doi: 10.1186/s12864-020-06990-4.
6
Pathogen-associated selection on innate immunity genes (TLR4, TLR7) in a neotropical rodent in landscapes differing in anthropogenic disturbance.在人为干扰程度不同的新热带地区，病原体相关的固有免疫基因（TLR4、TLR7）选择。
Heredity (Edinb). 2020 Oct;125(4):184-199. doi: 10.1038/s41437-020-0331-y. Epub 2020 Jul 2.
7
Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak.持久和高毒力布鲁氏菌病暴发的阿尔卑斯野山羊遗传流行病学研究。
Sci Rep. 2020 Mar 10;10(1):4400. doi: 10.1038/s41598-020-61299-2.
8
Adaptive landscape genetics and malaria across divergent island bird populations.适应性景观遗传学与不同岛屿鸟类种群中的疟疾
Ecol Evol. 2019 Oct 2;9(22):12482-12502. doi: 10.1002/ece3.5700. eCollection 2019 Nov.
9
The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries).在一个野生的斯欧绵羊（Ovis aries）群体中，针对寄生虫特异性免疫反应的遗传结构。
PLoS Genet. 2019 Nov 7;15(11):e1008461. doi: 10.1371/journal.pgen.1008461. eCollection 2019 Nov.
10
Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon.汞暴露和营养状况不良会降低儿童对六种扩大免疫规划疫苗的反应：秘鲁亚马逊受金矿开采影响社区的一项观察性队列研究。
Int J Environ Res Public Health. 2019 Feb 21;16(4):638. doi: 10.3390/ijerph16040638.
本文引用的文献
1
Infection ... by the new genetics.受新遗传学影响的感染……
J Infect. 1996 Jul;33(1):1-5. doi: 10.1016/s0163-4453(96)92605-5.
2
3
The influence of genetic factors on the immune response as judged by pneumococcal vaccination of mono- and dizygotic Caucasian twins.通过对单卵和双卵白种人双胞胎进行肺炎球菌疫苗接种来判断遗传因素对免疫反应的影响。
Clin Exp Immunol. 1993 Jun;92(3):532-6. doi: 10.1111/j.1365-2249.1993.tb03433.x.
4
Helicobacter pylori infection: genetic and environmental influences. A study of twins.幽门螺杆菌感染：遗传和环境影响。一项双胞胎研究。
Ann Intern Med. 1994 Jun 15;120(12):982-6. doi: 10.7326/0003-4819-120-12-199406150-00002.
5
Genetic control of host resistance to infection.宿主抗感染的遗传控制。
Trends Genet. 1994 Oct;10(10):365-71. doi: 10.1016/0168-9525(94)90133-3.
6
Fc gamma receptor IIa (CD32) polymorphism in fulminant meningococcal septic shock in children.儿童暴发性脑膜炎球菌败血症中Fcγ受体IIa（CD32）多态性
J Infect Dis. 1994 Oct;170(4):848-53. doi: 10.1093/infdis/170.4.848.
7
T cell receptor V beta gene expression in monozygotic twins. Discordance in CD8 subset and in disease states.单卵双胞胎中T细胞受体Vβ基因的表达。CD8亚群及疾病状态的不一致性。
J Immunol. 1994 Jan 1;152(1):315-21.
8
Recombination rates across the HLA complex: use of microsatellites as a rapid screen for recombinant chromosomes.HLA复合体的重组率：利用微卫星作为重组染色体的快速筛选方法。
Hum Mol Genet. 1995 Mar;4(3):423-8. doi: 10.1093/hmg/4.3.423.
9
Mapping of genes controlling quantitative antibody production in Biozzi mice.Biozzi小鼠中控制定量抗体产生的基因定位
J Immunol. 1995 Jun 1;154(11):5799-805.
10
Presentation of the Plasmodium falciparum antigen Pf155/RESA to human T cells. Variations in responsiveness induced by antigen presenting cells from different but MHC class II identical donors.恶性疟原虫抗原Pf155/RESA向人T细胞的呈递。来自不同但MHC II类相同供体的抗原呈递细胞诱导的反应性变化。
Immunol Lett. 1994 Dec;43(1-2):59-66. doi: 10.1016/0165-2478(94)00163-4.
Zotero 插件