通过对单卵和双卵白种人双胞胎进行肺炎球菌疫苗接种来判断遗传因素对免疫反应的影响。
The influence of genetic factors on the immune response as judged by pneumococcal vaccination of mono- and dizygotic Caucasian twins.
作者信息
Konradsen H B, Henrichsen J, Wachmann H, Holm N
机构信息
Department of Bacteriology, Statens Seruminstitut, Copenhagen, Denmark.
出版信息
Clin Exp Immunol. 1993 Jun;92(3):532-6. doi: 10.1111/j.1365-2249.1993.tb03433.x.
Abstract
Eighty-four mono- and dizygotic Caucasian twins randomly chosen, except for age and sex distribution, were vaccinated with a 23-valent pneumococcal vaccine. Blood samples were drawn before and after vaccination and the concentration of IgG, IgG1 and IgG2 pneumococcal antibodies was measured using an ELISA technique which only detects type-specific capsular antibodies, since C-polysaccharide antibodies in serum were removed. A significantly closer correlation was found regarding mean IgG and IgG2 antibody concentrations after vaccination in mono- compared with dizygotic twins, and this correlation was seemingly type-specific. Since environmental factors in our study population should not contribute more to the immune response in one type of twins compared with the other, we conclude that genetic factors influence the IgG and IgG2 antibody response to pneumococcal vaccination, and that this influence seems to be type-dependent.
摘要
除年龄和性别分布外，随机选取84对单卵和双卵高加索双胞胎，用23价肺炎球菌疫苗进行接种。在接种前后采集血样，采用ELISA技术测定IgG、IgG1和IgG2肺炎球菌抗体的浓度，该技术仅检测型特异性荚膜抗体，因为血清中的C多糖抗体已被去除。与双卵双胞胎相比，单卵双胞胎接种后平均IgG和IgG2抗体浓度的相关性显著更高，且这种相关性似乎是型特异性的。由于我们研究人群中的环境因素对一种双胞胎免疫反应的影响不应高于另一种双胞胎，因此我们得出结论，遗传因素影响对肺炎球菌疫苗接种的IgG和IgG2抗体反应，且这种影响似乎是型依赖性的。
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