Pugh S C, Jones N C, Barsoum L Z
Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
Anaesthesia. 1996 Dec;51(12):1162-4. doi: 10.1111/j.1365-2044.1996.tb15060.x.
In a prospective, randomised, double-blind trial, we assessed the relative efficacy of prophylactic ondansetron and metoclopramide administration in the reduction of postoperative nausea and vomiting in 60 patients undergoing routine major neurosurgical procedures. The patients were randomly allocated into one of two groups. Both groups received a standardised anaesthetic. When the dura mater was closed, patients in group A received an intravenous injection of metoclopramide 10 mg whilst group B received ondansetron 8 mg intravenously. Patients who received metoclopramide experienced less postoperative nausea and vomiting than those who received ondansetron in the 48 h following surgery (17 (56%) versus 9 (30%) p = 0.038). In the light of these findings, we believe that ondansetron is an inappropriate agent for the prevention of postoperative nausea and vomiting in the neurosurgical population.
在一项前瞻性、随机、双盲试验中，我们评估了预防性使用昂丹司琼和甲氧氯普胺对60例行常规大型神经外科手术患者术后恶心和呕吐的缓解效果。患者被随机分为两组。两组均接受标准化麻醉。当硬脑膜闭合时，A组患者静脉注射10毫克甲氧氯普胺，而B组患者静脉注射8毫克昂丹司琼。在术后48小时内，接受甲氧氯普胺的患者比接受昂丹司琼的患者术后恶心和呕吐的发生率更低（分别为17例（56%）和9例（30%），p = 0.038）。鉴于这些发现，我们认为昂丹司琼不适用于预防神经外科患者的术后恶心和呕吐。
