Kono Y, Moriyasu F, Mine Y, Nada T, Kamiyama N, Suginoshita Y, Matsumura T, Kobayashi K, Chiba T
Department of Gastroenterology and Hepatology, Kyoto University, School of Medicine, Japan.
Invest Radiol. 1997 Feb;32(2):120-5. doi: 10.1097/00004424-199702000-00008.
The authors evaluate the efficacy of SHU 508A, a galactose-based contrast agent used in gray-scale second harmonic imaging in vitro and in vivo experiments.
A Toshiba prototype harmonic imaging system (2.5/5.0 MHz) was used with SHU 508A in a phantom experiment and to image the liver in five healthy rabbits and one rabbit that had VX-2 tumors in the liver.
In the second harmonic imaging, most of the fundamental components of the backscattered echo were eliminated, and good images with high contrast were obtained in the phantom experiment. Liver parenchyma was enhanced clearly in all rabbits at 0.3 mL/kg, an effect that lasted for 90 seconds. The tumor, which was mostly necrotic, was depicted clearly as a negative enhanced area surrounded by enhanced healthy liver.
Gray-scale second harmonic imaging is a promising new method for visualization of perfusion of organs.
作者评估了SHU 508A的有效性，它是一种用于灰阶二次谐波成像的基于半乳糖的造影剂，进行了体外和体内实验。
在体模实验中使用配备SHU 508A的东芝原型谐波成像系统（2.5/5.0兆赫），对五只健康兔子和一只肝脏有VX - 2肿瘤的兔子的肝脏进行成像。
在二次谐波成像中，背向散射回波的大部分基波成分被消除，在体模实验中获得了高对比度的良好图像。所有兔子在注射剂量为0.3 mL/kg时肝脏实质明显增强，这种效果持续90秒。肿瘤大部分为坏死组织，清晰显示为被增强的健康肝脏包围的负增强区域。
灰阶二次谐波成像是一种很有前景的用于观察器官灌注的新方法。
