Lander H M
Department of Biochemistry, Cornell University Medical College, New York 10021, USA.
FASEB J. 1997 Feb;11(2):118-24.
It is well accepted that extracellular ligands trigger nuclear signals through a cascade of protein-protein interactions. Many of these pathways have been carefully defined and provide an important framework by which we can understand and intervene in the processes they initiate. Recent data in the literature indicate that many extracellular ligands generate and/or require reactive free radicals or derived species to successfully transmit their signals to the nucleus. Thus, a novel signaling mechanism akin to one solely dependent on protein-protein interactions may exist. Here, we review this information, identify both the sources and targets of free radicals generated by various growth factors and cytokines, discuss how specificity can be achieved, and explore the pathophysiological implications.
细胞外配体通过一系列蛋白质-蛋白质相互作用触发核信号，这一点已被广泛接受。其中许多信号通路已得到详细定义，并提供了一个重要框架，通过该框架我们可以理解和干预它们所启动的过程。文献中的最新数据表明，许多细胞外配体产生和/或需要活性自由基或衍生物种才能成功地将其信号传递到细胞核。因此，可能存在一种类似于仅依赖蛋白质-蛋白质相互作用的新型信号传导机制。在此，我们回顾这些信息，确定各种生长因子和细胞因子产生的自由基的来源和靶点，讨论如何实现特异性，并探讨其病理生理学意义。
