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小儿对乙酰氨基酚过量的结局及导致肝毒性的因素。

Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.

作者信息

Rivera-Penera T, Gugig R, Davis J, McDiarmid S, Vargas J, Rosenthal P, Berquist W, Heyman M B, Ament M E

机构信息

University of California, Medical Center, Los Angeles 90095, USA.

出版信息

J Pediatr. 1997 Feb;130(2):300-4. doi: 10.1016/s0022-3476(97)70359-7.

DOI:10.1016/s0022-3476(97)70359-7
PMID:9042136
Abstract

Seventy-three medical records of pediatric patients admitted for acetaminophen overdose were reviewed. Twenty-eight patients (39%) had severe liver toxic effects, and six of them underwent liver transplantation. Multiple miscalculated overdoses given by parents, with delay in therapy, are risk factors and the major cause of overdose in children 10 years of age or younger.

摘要

回顾了73例因对乙酰氨基酚过量而入院的儿科患者的病历。28例患者(39%)出现严重肝毒性反应,其中6例接受了肝移植。父母多次误算过量用药剂量且治疗延迟是10岁及以下儿童过量用药的危险因素和主要原因。

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Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.小儿对乙酰氨基酚过量的结局及导致肝毒性的因素。
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