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肠炎沙门氏菌中具有头孢菌素酶特性的新型可转移β-内酰胺耐药性

Novel transferable beta-lactam resistance with cephalosporinase characteristics in Salmonella enteritidis.

作者信息

Gaillot O, Clément C, Simonet M, Philippon A

机构信息

Department of Microbiology, King Fahd Military Medical Complex, Dhahran, Kingdom of Saudi Arabia.

出版信息

J Antimicrob Chemother. 1997 Jan;39(1):85-7. doi: 10.1093/jac/39.1.85.

DOI:10.1093/jac/39.1.85
PMID:9044032
Abstract

An isolate of Salmonella enteritidis was found to produce a plasmid-encoded beta-lactamase (DHA-1) that conferred resistance to extended-spectrum cephalosporins and cephamycins. The substrate and inhibition profiles of this enzyme resemble a class C beta-lactamase. This is the first report of a plasmid-mediated cephalosporinase of this class in the Salmonella genus.

摘要

一株肠炎沙门氏菌被发现可产生一种质粒编码的β-内酰胺酶（DHA-1），该酶可使细菌对超广谱头孢菌素和头霉素产生耐药性。这种酶的底物和抑制谱类似于C类β-内酰胺酶。这是沙门氏菌属中此类质粒介导的头孢菌素酶的首次报道。

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