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[亲脂性溶血素在红细胞膜上形成的孔的异质性]

[Heterogeneity of pores formed in erythrocyte membrane by lipophilic hemolysins].

作者信息

Chernitskiĭ E A, Sen'kovich O A, Kozlova N M

出版信息

Biofizika. 1996 Nov-Dec;41(6):1270-4.

PMID:9044620
Abstract

Concentration dependences of the rate of hemolysis are studied for ascorbic acid, sodium dodecylsulfate, triton X-100, ethyl and butyl alcohols. The double logarithmic plot of this dependence for ascorbic acid presents the straight line with the slope (n) of 2, meaning that two hemolytic molecules are necessary for the formation of one pore in the membrane. Other hemolysins are characterized by the curves with n changing from 2 to 24 as hemolysin concentration increases. The nonlinearity of plots found is considered as a consequence of the heterogeneity of pores, which are formed in the membrane bilayer as hemolysin concentration increases.

摘要

研究了抗坏血酸、十二烷基硫酸钠、曲拉通X-100、乙醇和丁醇溶血速率的浓度依赖性。抗坏血酸这种依赖性的双对数图呈现出斜率(n)为2的直线,这意味着在膜中形成一个孔需要两个溶血分子。其他溶血素的特征是随着溶血素浓度增加,n值从2变化到24的曲线。所发现的图的非线性被认为是孔的异质性的结果,这些孔是随着溶血素浓度增加在膜双分子层中形成的。

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