Grella C E, Anglin M D, Wugalter S E
UCLA Drug Abuse Research Center 90024, USA.
Am J Drug Alcohol Abuse. 1997 Feb;23(1):15-42. doi: 10.3109/00952999709001685.
This paper reports on the patterns of cocaine use among subjects (N = 427) admitted to a methadone maintenance treatment demonstration project designed to reduce risk for HIV. Assessments were conducted at intake and at approximately 18-24 months after treatment admission. Self-reported data on cocaine use was compared with results of urinalysis tests at both intake and follow-up; 29 subjects who falsely reported no use were recorded as users. Over one-third used some form of cocaine at both intake and follow-up, while approximately 30% abstained at both points. Approximately 20% ceased as well as initiated cocaine use between intake and follow-up. Use of powder cocaine, either alone or combined with heroin in "speedballs," decreased at follow-up, whereas crack use increased. Discriminant function analyses were performed to determine the predictors of the different patterns of cocaine use by type. Receipt of enhanced methadone treatment compared with standard methadone treatment, treatment duration, or average duration of counselor contact appeared unrelated to cocaine use. Cocaine use at follow-up was associated with polydrug and alcohol use, illegal activity, a negative emotional state, and sex work. Crack users were more likely to be African American than nonusers; continuous users of powder cocaine were more likely to also be using heroin than were nonusers; and continuous speedball users were more likely to be women sex workers with high levels of depression. This analysis demonstrated that cessation or continuation of cocaine use after entry into methadone maintenance treatment is not uniform across different types of cocaine.
本文报告了参与一项旨在降低艾滋病毒感染风险的美沙酮维持治疗示范项目的受试者(N = 427)的可卡因使用模式。在入组时以及治疗入组后约18 - 24个月进行评估。将可卡因使用的自我报告数据与入组时和随访时的尿液分析测试结果进行比较;29名虚报未使用可卡因的受试者被记录为使用者。超过三分之一的受试者在入组和随访时都使用了某种形式的可卡因,而约30%的受试者在这两个时间点都 abstained。约20%的受试者在入组和随访期间停止并开始使用可卡因。随访时,单独使用粉末可卡因或与海洛因混合在“速球”中使用的情况减少,而快克可卡因的使用增加。进行判别函数分析以确定不同类型可卡因使用模式的预测因素。与标准美沙酮治疗相比,接受强化美沙酮治疗、治疗持续时间或咨询师接触的平均持续时间似乎与可卡因使用无关。随访时的可卡因使用与多药和酒精使用、非法活动、负面情绪状态以及性工作有关。快克可卡因使用者比非使用者更可能是非裔美国人;粉末可卡因的持续使用者比非使用者更可能同时使用海洛因;而持续使用“速球”的使用者更可能是患有严重抑郁症的女性性工作者。该分析表明,进入美沙酮维持治疗后,不同类型可卡因的使用停止或持续情况并不一致。