Gaard M, Tretli S, Urdal P
Cancer Registry of Norway, Institute for Epidemiological Cancer Research, Ultevål Hospital, Oslo, Norway.
Scand J Gastroenterol. 1997 Feb;32(2):162-8. doi: 10.3109/00365529709000187.
Concern has been raised that a low total serum cholesterol level, although beneficial for cardiovascular diseases, may increase the risk of cancer. This prospective cohort study analyses the hypotheses that a low total serum cholesterol level or its subfractions (serum low-density-lipoprotein cholesterol, high-density-lipoprotein cholesterol, and triglycerides) increase the risk of cancer of the colon and rectum.
Between 1977 and 1983, 62,173 men and women attended a health screening carried out by the Norwegian National Health Screening Service. The screening consisted of a questionnaire, anthropometric measurements, and samples of non-fasting blood drawn for analyses of serum total cholesterol, low-density-lipoprotein cholesterol, high-density-lipoprotein cholesterol, and triglycerides.
During the 7- to 13-year follow-up, 186 patients were found to have colon cancer and 106 rectal cancer by linkage to the Norwegian Cancer Registry. Among men there were no associations between blood lipid and lipoprotein levels and risk of cancer of the proximal colon, distal colon, or the rectum. Among women there was a formal statistically significant inverse relationship between level of total cholesterol and low-density-lipoprotein cholesterol and risk of distal colon cancer, and a positive trend between total cholesterol level and rectal cancer.
The statistically significant results among women were interpreted as incidental, and we conclude that blood lipid and lipoprotein levels were not associated with the risk of colon or rectum cancer in men or women in this cohort.
有人担心，尽管总血清胆固醇水平低对心血管疾病有益，但可能会增加患癌风险。这项前瞻性队列研究分析了以下假设：总血清胆固醇水平低或其亚组分（血清低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯）会增加患结肠癌和直肠癌的风险。
1977年至1983年间，62173名男性和女性参加了挪威国家健康筛查服务中心进行的健康筛查。筛查包括一份问卷、人体测量以及抽取非空腹血样以分析血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯。
在7至13年的随访期间，通过与挪威癌症登记处的关联，发现186例患有结肠癌，106例患有直肠癌。在男性中，血脂和脂蛋白水平与近端结肠癌、远端结肠癌或直肠癌的风险之间没有关联。在女性中，总胆固醇和低密度脂蛋白胆固醇水平与远端结肠癌风险之间存在统计学上显著的负相关，总胆固醇水平与直肠癌之间存在正相关趋势。
女性中具有统计学意义的结果被解释为偶然现象，我们得出结论，在该队列中，男性或女性的血脂和脂蛋白水平与结肠癌或直肠癌风险无关。
