Fries W, Grassi S A, Leone L, Giacomin D, Galeazzi F, Naccarato R, Martin A
Division of Gastroenterology, University of Padua, Italy.
Scand J Gastroenterol. 1995 Dec;30(12):1221-3. doi: 10.3109/00365529509101635.
Common etiopathogenic factors may explain the association of systemic sarcoidosis with inflammatory bowel disease.
We report two cases of such an association: one of sarcoidosis that developed 2 years after proctocolectomy for ulcerative colitis and one of sarcoidosis and Crohn's colitis. Factors like increased cellular immunity or circulating immunocomplexes or autoantibodies may have a role. Exogenous agents or familiarity may also be involved.
It is postulated that the association between sarcoidosis and inflammatory bowel disease (both ulcerative colitis and Crohn's disease) does not occur by chance alone and that the two conditions may share some genetic or immunologic alterations. The two diseases, however, follow an independent clinical course.
常见的致病因素可能解释系统性结节病与炎症性肠病之间的关联。
我们报告了两例这种关联的病例：一例是在溃疡性结肠炎行直肠结肠切除术后2年发生的结节病，另一例是结节病合并克罗恩氏结肠炎。细胞免疫增强、循环免疫复合物或自身抗体等因素可能起作用。外源性因素或家族性因素也可能有关。
据推测，结节病与炎症性肠病（溃疡性结肠炎和克罗恩病）之间的关联并非偶然发生，这两种疾病可能存在一些共同的基因或免疫改变。然而，这两种疾病遵循各自独立的临床病程。
