酿酒酵母中相邻减数分裂重组热点之间的竞争
Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae.
作者信息
Fan Q Q, Xu F, White M A, Petes T D
机构信息
Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
出版信息
Genetics. 1997 Mar;145(3):661-70. doi: 10.1093/genetics/145.3.661.
Abstract
In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.
摘要
在酿酒酵母的野生型菌株中，减数分裂重组热点位于HIS4基因的上游。将一段49个碱基对的端粒序列插入HIS4的编码区域会强烈刺激减数分裂重组以及减数分裂特异性双链DNA断裂（DSB）的局部形成。当构建两个热点均为杂合的菌株时，与位于不同染色体上相比，位于同一条染色体上的热点活性显著降低。
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