Ni A P, Lin G Y, Yang L, He H Y, Huang C W, Liu Z J, Wang R S, Zhang J S, Yu J Y, Li N, Wang J B, Yang H Y
Department of Clinical Laboratories, Peking Union Medical College Hospital, CAMS, Beijing PR China.
Scand J Infect Dis. 1996;28(6):553-7. doi: 10.3109/00365549609037959.
To evaluate and compare the prevalence of antibodies to 3 chlamydial species in various populations on the mainland of China, the MIF test was used to detect both serum IgG and IgM antibodies to these species in the normal population (n = 711), in poultry workers (n = 51), in female prostitutes (n = 106), in patients attending the sexually transmitted diseases clinic (n = 98), and in adult patients with pneumonia and bronchitis (n = 108). In the normal population, IgG antibodies against C. pneumoniae, C. trachomatis and C. psittaci were present in 61.5%, 9.3%, and 3.5%, respectively, and increasing with age. Prevalence and geometric mean titers (GMT) of IgG antibodies to C. trachomatis in prostitutes (54.7%) and female (55%), but not male (15.4%) sexually transmitted disease patients were significantly higher than in the normal adult female population. The prevalence indicating both previous and recent C. psittaci infections in poultry workers was no higher than in the others. The prevalence of IgG antibodies and GMT to C. pneumoniae in patients with pneumonia and bronchitis was not statistically higher than in the normal adult population. Evidence of cross-reactivities in the MIF test between different species was found in both prevalence and GMT. Serum IgM antibodies were usually absent in patients who met the serological criteria of recent C. pneumoniae infection, indicating that most of them could be considered as reinfections. On the basis of our survey, acute antibodies to C. pneumoniae by the MIF test, if they are detected, may be valuable in the diagnosis of recent C. pneumoniae infections.
为了评估和比较中国大陆不同人群中针对3种衣原体的抗体流行情况，采用微量免疫荧光试验（MIF）检测正常人群（n = 711）、家禽从业者（n = 51）、女性性工作者（n = 106）、性病门诊患者（n = 98）以及成年肺炎和支气管炎患者（n = 108）血清中针对这些衣原体的IgG和IgM抗体。在正常人群中，抗肺炎衣原体、沙眼衣原体和鹦鹉热衣原体的IgG抗体阳性率分别为61.5%、9.3%和3.5%，且随年龄增长而升高。性工作者（54.7%）和女性（55%）性病患者中沙眼衣原体IgG抗体的流行率和几何平均滴度（GMT）显著高于正常成年女性人群，但男性（15.4%）性病患者中该抗体流行率和GMT与正常成年女性人群相比无显著差异。家禽从业者中鹦鹉热衣原体既往和近期感染的流行率并不高于其他人群。肺炎和支气管炎患者中肺炎衣原体IgG抗体的流行率和GMT与正常成年人群相比无统计学差异。在MIF试验中发现不同衣原体之间在流行率和GMT方面存在交叉反应。符合近期肺炎衣原体感染血清学标准的患者通常血清中不存在IgM抗体，这表明其中大多数可被视为再次感染。基于我们的调查，通过MIF试验检测到的肺炎衣原体急性抗体，若能检测到，可能对近期肺炎衣原体感染的诊断有价值。
