Roth G S, Kowatch M A, Hengemihle J, Ingram D K, Spangler E L, Johnson L K, Lane M A
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA.
J Gerontol A Biol Sci Med Sci. 1997 Mar;52(2):B98-102. doi: 10.1093/gerona/52a.2.b98.
Cutaneous wounds close more slowly in rats and monkeys as age increases. Caloric restriction of 40% in rats and 30% in monkeys did not significantly affect healing rates, although it did exert a trend toward faster closure. Similarly, voluntary exercise did not significantly alter healing rates in rats. Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established.
随着年龄增长，大鼠和猴子的皮肤伤口愈合速度会更慢。对大鼠进行40%的热量限制，对猴子进行30%的热量限制，虽然有愈合加快的趋势，但并未显著影响愈合率。同样，自愿运动也未显著改变大鼠的愈合率。因此，伤口愈合受损似乎是衰老的一种普遍生理表现，但其能否通过“抗衰老”干预得到改善仍有待确定。
