Aguinaga Ontoso I, Guillen Grima F, Aguinaga Ontoso E, Fernandez Fernandez L R
Department of Health, City of Pamplona, Spain.
Eur J Epidemiol. 1997 Jan;13(1):19-23. doi: 10.1023/a:1007324907818.
Glaucoma is a serious disease that may cause a decrease in peripheral vision as well as blindness. Although the treatment of extreme levels of high intraocular pressure (p > 35 mm) reduces the risk of glaucoma it is not known if the treatment of mild and moderate intraocular pressure prevents the onset of glaucoma. A bibliographic search in Medline CD-ROM was performed from 1967 to 1995, as well as in SIGLE CD-ROM. The keywords used were 'glaucoma prevention' and 'glaucoma suspects'. After the search 18 papers which treated moderate and mild intraocular pressure were selected. Of all these papers, those that used the same methodology; randomization and timolol as treatment, were chosen. The possibility of publication bias was controlled by plotting effect size vs. number of papers, as well as effect size vs. year of publication. A meta-analysis using two methods, weighted zetas and adding zetas, was performed. The combined effect size was -6.25%, and the weighted effect size was -6.45%. We computed the pooled z by two methods: adding Zs and adding weighted Zs. The Z obtained by adding Zs has a value of 2.31120 p = 0.0177, one tail). Using the method of adding weighted Zs we obtained a value of 2.4201 (p = 0.0082, one tail). Our results show that the treatment with timolol of patients with mild and moderate intraocular pressure may help to prevent the onset of glaucoma.
青光眼是一种严重的疾病，可能导致周边视力下降甚至失明。尽管治疗极高眼压水平（眼压>35毫米汞柱）可降低青光眼风险，但尚不清楚治疗轻度和中度眼压是否能预防青光眼的发生。我们在1967年至1995年期间检索了Medline光盘数据库以及SIGLE光盘数据库。使用的关键词是“青光眼预防”和“青光眼疑似病例”。检索后，我们选择了18篇治疗轻度和中度眼压的论文。在所有这些论文中，我们挑选了那些采用相同方法（随机化和使用噻吗洛尔进行治疗）的论文。通过绘制效应量与论文数量以及效应量与发表年份的关系图来控制发表偏倚的可能性。我们使用加权ζ法和相加ζ法两种方法进行了荟萃分析。合并效应量为-6.25%，加权效应量为-6.45%。我们通过两种方法计算合并Z值：相加Zs和相加加权Zs。通过相加Zs得到的Z值为2.3112（p = 0.0177，单尾）。使用相加加权Zs的方法，我们得到的值为2.4201（p = 0.0082，单尾）。我们的结果表明，用噻吗洛尔治疗轻度和中度眼压患者可能有助于预防青光眼的发生。
