培养过程中与亚历山大藻属（甲藻门）相关的细菌产生麻痹性贝类毒素的证据。
Evidence for production of paralytic shellfish toxins by bacteria associated with Alexandrium spp. (Dinophyta) in culture.
作者信息
Gallacher S, Flynn K J, Franco J M, Brueggemann E E, Hines H B
机构信息
SOAEFD, Marine Laboratory, Aberdeen, United Kingdom.
出版信息
Appl Environ Microbiol. 1997 Jan;63(1):239-45. doi: 10.1128/aem.63.1.239-245.1997.
Abstract
A substantial proportion of bacteria from five Alexandrium cultures originally isolated from various countries produced sodium channel blocking (SCB) toxins, as ascertained by mouse neuroblastoma assay. The quantities of SCB toxins produced by bacteria and dinoflagellates were noted, and the limitations in comparing the toxicities of these two organisms are discussed. The chemical nature of the SCB toxins in selected bacterial isolates was determined as paralytic shellfish toxins by pre- and postcolumn high-performance liquid chromatography, capillary electrophoresis-mass spectrometry, and enzyme immunoassay.
摘要
通过小鼠神经母细胞瘤试验确定，最初从不同国家分离出的五种亚历山大藻培养物中的相当一部分细菌产生了钠通道阻断（SCB）毒素。记录了细菌和甲藻产生的SCB毒素的量，并讨论了比较这两种生物毒性的局限性。通过柱前和柱后高效液相色谱、毛细管电泳-质谱和酶免疫测定法，确定了所选细菌分离物中SCB毒素的化学性质为麻痹性贝类毒素。
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