Fachin A L, Maffei C M, Martinez-Rossi N M
Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, USP, Brazil.
Mycopathologia. 1996;135(3):141-3. doi: 10.1007/BF00632334.
The in vitro susceptibility of three clinical Trichophyton rubrum isolates to griseofulvin and tioconazole, determined by the minimal inhibitory concentration (MIC), was 2 and 0.5 to 1.0 micrograms/ml, respectively. One mutant (gril) obtained after mutagenic treatment of one of these isolates was selected and showed simultaneous resistance to griseofulvin (MIC > 2000 micrograms/ml) and tioconazole (MIC = 1.0 microgram/ml). The clinical importance and the possibility of a multidrug resistance (MDR)-type mechanism being involved in this event is discussed.
通过最小抑菌浓度（MIC）测定，三种红色毛癣菌临床分离株对灰黄霉素和噻康唑的体外药敏分别为2微克/毫升和0.5至1.0微克/毫升。对其中一株进行诱变处理后获得的一个突变体（gril）被挑选出来，它对灰黄霉素（MIC>2000微克/毫升）和噻康唑（MIC = 1.0微克/毫升）同时耐药。本文讨论了这一事件的临床重要性以及多药耐药（MDR）型机制参与其中的可能性。
