Simmons D B, Schuman B M, Griffin J W
Section of Gastroenterology, Medical College of Georgia, USA.
J Fla Med Assoc. 1997 Feb;84(2):101-3.
Achalasia is a disease of undertermined etiology characterized by a defect in the innervation of esophageal smooth muscle causing aperistalsis of the esophageal body, increased lower esophageal sphnicter (LES) tone and inappropriate relaxation of the LES during swallowing. Several of the manometric and radiographic features of achalasia are also seen in individuals without the disease but they are reported much more frequently in older populations. We reviewed our cases of new onsst achalasia in patients over age 65 to see if their presentation and response to treatment might differ from that reported in younger patients. We found dysphagia to be the predominant symptom in our elderly patients just as it is in younger patients. Chest pain, on the other hand, was significantly less common. Additionally, our achalasia group had a high response rate to pneumatic dilatation, confirming an earlier study that showed greater efficacy in older patients than in younger patients.
贲门失弛缓症是一种病因不明的疾病，其特征是食管平滑肌神经支配缺陷，导致食管体部蠕动消失、食管下括约肌（LES）张力增加以及吞咽时LES不适当松弛。贲门失弛缓症的一些测压和影像学特征在无该疾病的个体中也可见，但在老年人群中报告更为频繁。我们回顾了65岁以上新诊断为贲门失弛缓症的患者病例，以观察他们的临床表现和对治疗的反应是否与年轻患者不同。我们发现吞咽困难是老年患者的主要症状，与年轻患者一样。另一方面，胸痛明显较少见。此外，我们的贲门失弛缓症组对气囊扩张术的反应率很高，证实了一项早期研究，该研究表明老年患者比年轻患者疗效更好。
