Burton G, Mason K V
Animal Skin and Allergy Clinic, Springwood, Queensland.
Aust Vet J. 1997 Feb;75(2):102-6. doi: 10.1111/j.1751-0813.1997.tb14167.x.
A soft tissue sarcoma occurred in the interscapular area of a cat, 1 to 7 months after vaccination at that site. The vaccine contained inactivated feline panleucopaenia virus combined with modified live feline herpesvirus and calicivirus. The tumour showed histological features of both fibrosarcoma and malignant fibrous histiocytoma. The tumour was observed to evolve from the site of a presumed postvaccinal granuloma. Local recurrence 6 weeks post excision necessitated more radical resection. Euthanasia was performed 2 years later when pleural effusion developed. The cause of effusion was not determined. There was no palpable evidence of local tumour regrowth at the time of euthanasia. A causal relationship between vaccination and sarcoma formation is considered based on the temporal association between the two events, the anatomical location of the tumour and histopathology consistent with postvaccinal sarcomas reported overseas. Six other vaccine site fibrosarcomas, potentially vaccine associated using the above criteria, are summarised.
一只猫在肩胛间区域接种疫苗1至7个月后发生了软组织肉瘤。该疫苗含有灭活的猫泛白细胞减少症病毒，以及改良活猫疱疹病毒和杯状病毒。肿瘤呈现出纤维肉瘤和恶性纤维组织细胞瘤的组织学特征。观察到肿瘤由一个推测的疫苗接种后肉芽肿部位发展而来。切除术后6周局部复发，需要进行更彻底的切除。2年后出现胸腔积液，遂实施安乐死。积液原因未明确。安乐死时未触及局部肿瘤复发的证据。基于这两个事件的时间关联、肿瘤的解剖位置以及与海外报道的疫苗接种后肉瘤一致的组织病理学，考虑疫苗接种与肉瘤形成之间存在因果关系。总结了另外6例根据上述标准可能与疫苗相关的疫苗接种部位纤维肉瘤。
