Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G
Laboratory for Glycobiology, University of Leuven, Belgium.
Genomics. 1997 Feb 15;40(1):24-30. doi: 10.1006/geno.1996.4518.
The four vertebrate glypican-related integral membrane proteoglycans identified so far constitute a discrete family of heparan sulfate proteoglycans that are linked to the cell surface via glycosyl phosphatidylinositol. In addition to the GPI anchor and substitution with heparan sulfate, the members of this family show significant sequence homology and share a unique and characteristic cysteine motif. Starting from an EST entry that showed significant sequence similarity to MXR7 and OCI-5 (coding, respectively, for human and rat glypican-3), we have isolated a human cDNA coding for glypican-5, a novel member of this proteoglycan family. The gene for this novel glypican (GPC5) maps to 13q32. In the adult, it is primarily expressed in brain tissue.
目前已鉴定出的四种脊椎动物硫酸乙酰肝素蛋白聚糖相关的整合膜蛋白聚糖，构成了一个离散的硫酸乙酰肝素蛋白聚糖家族，它们通过糖基磷脂酰肌醇与细胞表面相连。除了糖基磷脂酰肌醇锚定和硫酸乙酰肝素取代外，该家族成员还表现出显著的序列同源性，并共享一个独特的特征性半胱氨酸基序。从一个与MXR7和OCI-5（分别编码人源和大鼠源的磷脂酰肌醇蛋白聚糖-3）具有显著序列相似性的EST条目开始，我们分离出了一个编码磷脂酰肌醇蛋白聚糖-5的人类cDNA，它是该蛋白聚糖家族的一个新成员。这个新的磷脂酰肌醇蛋白聚糖（GPC5）基因定位于13q32。在成年人中，它主要在脑组织中表达。
