转录：为何TAFs至关重要？
Transcription: why are TAFs essential?
作者信息
Hampsey M, Reinberg D
机构信息
Howard Hughes Medical Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.
出版信息
Curr Biol. 1997 Jan 1;7(1):R44-6. doi: 10.1016/s0960-9822(06)00018-2.
PMID:9072170
Abstract
The TAFs are transcription factors associated with the TATA-binding protein, and until recently they were assumed to link specific activators to the general transcription machinery. Recent results suggest that the essential functions of TAFs are not as coactivators of transcription but as determinants of promoter selectivity.
摘要
TAF是与TATA结合蛋白相关的转录因子，直到最近，人们一直认为它们将特定的激活因子与通用转录机制联系起来。最近的研究结果表明，TAF的基本功能并非作为转录的共激活因子，而是作为启动子选择性的决定因素。
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