一种高防护等级的仅用于啮齿动物的鼻吸入实验设施的构建与验证

The construction and validation of a high containment nose-only rodent inhalation facility.

作者信息

Hoskins J A, Brown R C, Cain K, Clouter A, Houghton C E, Bowskill C A, Hibbs L R

机构信息

MRC Toxicology Unit, University of Leicester, U.K.

出版信息

Ann Occup Hyg. 1997 Jan;41(1):51-61. doi: 10.1016/S0003-4878(96)00029-4.

DOI:10.1016/S0003-4878(96)00029-4

PMID:9072950

Abstract

A new nose-only inhalation facility for rodents has been designed and built for operation within a high containment glove box facility. All operations using the equipment, whether concerned with aerosol generation or animal handling and exposure are conducted under high containment with total operator protection. The facility has been used to investigate known carcinogenic fibres such as the amphiboles. It has been designed to be resistant to most chemicals, under the conditions of an experiment, and can be used with radioactive material within the limitations which would be imposed for radiological protection. This paper describes the construction and validation of the equipment using titanium dioxide.

摘要

一种专为啮齿动物设计的新型仅用于鼻腔吸入的设施已建成，可在高防护手套箱设施内运行。使用该设备进行的所有操作，无论是与气溶胶生成相关还是与动物处理及暴露相关，均在高度防护条件下进行，为操作人员提供全面保护。该设施已用于研究已知的致癌纤维，如闪石。它被设计成在实验条件下能抵抗大多数化学物质，并且在符合辐射防护规定的限制范围内可用于放射性物质。本文描述了使用二氧化钛的该设备的构造和验证情况。