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一项随机干预研究,旨在考察免费提供流感疫苗对免疫接种覆盖率的影响。

A randomised intervention study to examine the effect on immunisation coverage of making influenza vaccine available at no cost.

作者信息

Satterthwaite P

出版信息

N Z Med J. 1997 Feb 28;110(1038):58-60.

PMID:9076288
Abstract

AIMS

This study aims to assess the effects of two interventions on influenza vaccination coverage: a simple organisational strategy, and making the vaccine available free.

METHODS

Sixteen general practitioners in the Auckland region were randomly selected to participate. Patients over 65 years of these general practitioners were randomly allocated to control, letter of invitation for a flu vaccine, or offer of a free flu vaccine. Administration of a flu vaccine for each person in the study was documented in each general practitioner surgery. Vaccine coverage for each of the three groups was measured.

RESULTS

Results were available for 15 of the 16 participating general practitioners, a total of 2791 subjects. Immunisation coverage rates for control, letter of invitation and vaccine at no cost, were 17%, 27% and 45% respectively. Statistical analysis, allowing for the cluster method used to obtain subjects, showed risk ratios of 1.55 and 2.65 for the two interventions, with p values of < 0.00001.

CONCLUSIONS

A potential source of bias in this study is underreporting of administration of vaccine to people in group 1. Notwithstanding this potential bias, both interventions were highly effective at increasing the uptake of influenza vaccine in the elderly population. General practitioners should be recommended to routinely invite patients over 65 years to have a flu vaccine. Given the commitment of the Ministry of Health to the vaccination against influenza of people over 65, this study would suggest that serious consideration should be given to making the vaccine available at no cost to this age group.

摘要

目的

本研究旨在评估两种干预措施对流感疫苗接种覆盖率的影响:一种简单的组织策略,以及提供免费疫苗。

方法

随机选择奥克兰地区的16名全科医生参与研究。这些全科医生的65岁以上患者被随机分配至对照组、收到流感疫苗邀请信组或获得免费流感疫苗组。每位参与研究的人员的流感疫苗接种情况在各全科医生诊所均有记录。测量三组人群的疫苗接种覆盖率。

结果

16名参与研究的全科医生中有15名提供了结果,共涉及2791名研究对象。对照组、收到邀请信组和免费疫苗组的免疫接种覆盖率分别为17%、27%和45%。考虑到获取研究对象所采用的整群抽样方法进行的统计分析显示,两种干预措施的风险比分别为1.55和2.65,P值均<0.00001。

结论

本研究中一个潜在的偏倚来源是第一组人群疫苗接种情况的报告不足。尽管存在这一潜在偏倚,但两种干预措施在提高老年人群流感疫苗接种率方面均非常有效。建议全科医生常规邀请65岁以上患者接种流感疫苗。鉴于卫生部致力于为65岁以上人群接种流感疫苗,本研究表明应认真考虑为该年龄组人群免费提供疫苗。

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