Chappel S C
Ares-Serono, Inc., Randolph, Massachusetts 02368, USA.
Hum Reprod Update. 1995 Sep;1(5):479-87. doi: 10.1093/humupd/1.5.479.
The existence of a heterogeneous population of follicle stimulating hormone (FSH) was described many years ago. Other pituitary glycoproteins, such as thyroid stimulating hormone (TSH) and luteinizing hormone (LH) as well as placental human chorionic gonadotrophin (HCG) also exhibit heterogeneity. Because FSH plays a significant role in a variety of ovarian activities such as follicular maturation, selection of the dominant follicle and ovulation, the possible role of subpopulations of FSH with distinct physicochemical characteristics is of great interest. After a great deal of investigation, the physiological significance of this biochemical phenomenon has yet to be fully understood. Investigators have employed immunoassays, in-vitro bioassays and radioreceptor assays to study the biological activity of the individual isoforms of FSH. As more information has accumulated, it has become clear that some of the initial assumptions used to interpret data may be incorrect. This review is provided to update the reader with available information on the topic as it relates to FSH and to point out issues that require re-evaluation in this area.
多年前就已发现促卵泡激素（FSH）存在异质性群体。其他垂体糖蛋白，如促甲状腺激素（TSH）、黄体生成素（LH）以及胎盘人绒毛膜促性腺激素（HCG）也表现出异质性。由于FSH在多种卵巢活动中发挥重要作用，如卵泡成熟、优势卵泡的选择和排卵，具有不同物理化学特性的FSH亚群的潜在作用备受关注。经过大量研究，这种生化现象的生理意义尚未完全明了。研究人员采用免疫测定、体外生物测定和放射受体测定来研究FSH各个异构体的生物活性。随着更多信息的积累，很明显一些用于解释数据的最初假设可能是错误的。本综述旨在向读者提供与FSH相关的该主题的现有信息，并指出该领域需要重新评估的问题。
