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1
Reduced in vitro fertilization of human oocytes correlates with raised circulating FSH levels during ovarian stimulation in normogonadotropic women downregulated with GnRH-analogues.在使用促性腺激素释放激素类似物进行降调节的正常性腺功能女性中，卵巢刺激期间人卵母细胞体外受精率降低与循环卵泡刺激素水平升高相关。
J Assist Reprod Genet. 1997 Nov;14(10):581-8. doi: 10.1023/a:1022528617732.
2
Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment.在接受重组促卵泡激素和促性腺激素释放激素（GnRH）拮抗剂联合治疗进行卵巢刺激后的体外受精患者中，给予重组人绒毛膜促性腺激素、重组促黄体生成素或GnRH激动剂诱导最终卵母细胞成熟后，未补充黄体期的特征。
J Clin Endocrinol Metab. 2003 Sep;88(9):4186-92. doi: 10.1210/jc.2002-021953.
3
Do the suppression criteria in GnRH-a cycles predict in vitro fertilization outcome?GnRH-a周期中的抑制标准能否预测体外受精结局？
Gynecol Endocrinol. 1995 Jun;9(2):91-6. doi: 10.3109/09513599509160196.
4
The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict "low responders".垂体降调节后使用促性腺激素开始刺激时的血清卵泡刺激素与黄体生成素比值与成熟卵母细胞产量呈负相关，且可预测“低反应者”。
Fertil Steril. 2005 Apr;83(4):883-8. doi: 10.1016/j.fertnstert.2004.10.040.
5
Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization.在体外受精的卵巢过度刺激过程中，在与GnRH拮抗剂加尼瑞克联合治疗后，使用GnRH激动剂触发最终卵母细胞成熟后的内分泌情况。
J Clin Endocrinol Metab. 2002 Feb;87(2):709-15. doi: 10.1210/jcem.87.2.8197.
6
[Correlation between serum inhibin B level after treatment with gonadotropin releasing hormone agonist and outcome of in vitro fertilization-embryo transfer].促性腺激素释放激素激动剂治疗后血清抑制素B水平与体外受精-胚胎移植结局的相关性
Zhonghua Fu Chan Ke Za Zhi. 2009 Apr;44(4):260-2.
7
The effect of human menopausal gonadotrophin and highly purified, urine-derived follicle stimulating hormone on the outcome of in-vitro fertilization in down-regulated normogonadotrophic women.人绝经期促性腺激素与高纯度尿源性促卵泡生成素对降调节的正常促性腺激素水平女性体外受精结局的影响
Hum Reprod. 1996 Jun;11(6):1209-13. doi: 10.1093/oxfordjournals.humrep.a019357.
8
The effect of exogenous luteinizing hormone (LH) on oocyte viability: evidence from a comparative study using recombinant human follicle-stimulating hormone (FSH) alone or in combination with recombinant LH for ovarian stimulation in pituitary-suppressed women undergoing assisted reproduction.外源性促黄体生成素（LH）对卵母细胞活力的影响：来自一项比较研究的证据，该研究在垂体抑制的接受辅助生殖的女性中，单独使用重组人促卵泡生成素（FSH）或联合重组LH进行卵巢刺激。
J Assist Reprod Genet. 2001 May;18(5):250-6. doi: 10.1023/a:1016662100572.
9
Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation.在接受促性腺激素释放激素激动剂降调节和重组促卵泡激素刺激的辅助生殖女性中，卵泡中期促黄体生成素水平与卵巢反应及妊娠结局的关系。
Hum Reprod. 2002 Aug;17(8):2016-21. doi: 10.1093/humrep/17.8.2016.
10
Recombinant follicle-stimulating hormone and recombinant luteinizing hormone versus recombinant follicle-stimulating hormone alone during GnRH antagonist ovarian stimulation in patients aged ≥35 years: a randomized controlled trial.重组卵泡刺激素和重组促黄体生成素联合 GnRH 拮抗剂方案与单独使用重组卵泡刺激素方案在年龄≥35 岁患者卵巢刺激中的随机对照研究。
Hum Reprod. 2015 May;30(5):1188-95. doi: 10.1093/humrep/dev038. Epub 2015 Mar 3.

引用本文的文献

1
Requirements for human chorionic gonadotropin and recombinant human luteinizing hormone for follicular development and maturation.卵泡发育和成熟对人绒毛膜促性腺激素和重组人促黄体生成素的需求。
J Assist Reprod Genet. 1999 Sep;16(8):425-30. doi: 10.1023/a:1020569508927.

本文引用的文献

1
Heterogeneity of follicle stimulating hormone: control and physiological function.促卵泡激素的异质性：调控与生理功能
Hum Reprod Update. 1995 Sep;1(5):479-87. doi: 10.1093/humupd/1.5.479.
2
Cumulus cells of oocyte-cumulus complexes secrete a meiosis-activating substance when stimulated with FSH.卵母细胞-卵丘复合体的卵丘细胞在受到促卵泡激素刺激时会分泌一种减数分裂激活物质。
Mol Reprod Dev. 1997 Mar;46(3):296-305. doi: 10.1002/(SICI)1098-2795(199703)46:3<296::AID-MRD8>3.0.CO;2-K.
3
Premature luteinization in in vitro fertilization cycles using gonadotropin-releasing hormone agonist (GnRH-a) and recombinant follicle-stimulating hormone (FSH) and GnRH-a and urinary FSH.在使用促性腺激素释放激素激动剂（GnRH-a）与重组促卵泡生成素（FSH）以及GnRH-a与尿促卵泡素的体外受精周期中出现的过早黄素化。
Fertil Steril. 1996 Aug;66(2):275-80. doi: 10.1016/s0015-0282(16)58453-2.
4
The effect of human menopausal gonadotrophin and highly purified, urine-derived follicle stimulating hormone on the outcome of in-vitro fertilization in down-regulated normogonadotrophic women.人绝经期促性腺激素与高纯度尿源性促卵泡生成素对降调节的正常促性腺激素水平女性体外受精结局的影响
Hum Reprod. 1996 Jun;11(6):1209-13. doi: 10.1093/oxfordjournals.humrep.a019357.
5
In-vitro biopotency and glycoform distribution of recombinant human follicle stimulating hormone (Org 32489), Metrodin and Metrodin-HP.
Hum Reprod. 1995 Jul;10(7):1928-35. doi: 10.1093/oxfordjournals.humrep.a136208.
6
Regulation of ovarian androgen production: a key parameter to success during ovarian stimulation?卵巢雄激素生成的调节：卵巢刺激过程中成功的关键参数？
Hum Reprod. 1995 Sep;10(9):2227-33. doi: 10.1093/oxfordjournals.humrep.a136274.
7
Luteinizing hormone: its role, mechanism of action, and detrimental effects when hypersecreted during the follicular phase.促黄体生成素：其作用、作用机制以及在卵泡期分泌过多时的有害影响。
Fertil Steril. 1993 Jun;59(6):1153-61. doi: 10.1016/s0015-0282(16)55968-8.
8
Advancement of meiotic resumption in graafian follicles reduces fertility in the rat.格拉夫卵泡减数分裂恢复的提前会降低大鼠的生育能力。
Gynecol Obstet Invest. 1993;36(3):129-35. doi: 10.1159/000292611.
9
Multiple follicular development and ovarian steroidogenesis following subcutaneous administration of a highly purified urinary FSH preparation in pituitary desensitized women undergoing IVF: a multicentre European phase III study.在接受体外受精的垂体脱敏女性中皮下注射高纯度尿促卵泡素制剂后的多个卵泡发育和卵巢甾体激素生成：一项欧洲多中心III期研究
Hum Reprod. 1994 Mar;9(3):424-30. doi: 10.1093/oxfordjournals.humrep.a138522.
10
Experimental extension of the time interval between oocyte maturation and ovulation: effect on fertilization and first cleavage.卵母细胞成熟与排卵之间时间间隔的实验性延长：对受精和首次卵裂的影响。
Fertil Steril. 1995 Nov;64(5):1023-8. doi: 10.1016/s0015-0282(16)57922-9.

在使用促性腺激素释放激素类似物进行降调节的正常性腺功能女性中，卵巢刺激期间人卵母细胞体外受精率降低与循环卵泡刺激素水平升高相关。

Reduced in vitro fertilization of human oocytes correlates with raised circulating FSH levels during ovarian stimulation in normogonadotropic women downregulated with GnRH-analogues.

作者信息

Andersen C Y, Westergaard L G, Byskov A G, Erb K

机构信息

Laboratory of Reproductive Biology, Juliane Marie Center for Children, Women and Reproduction, University Hospital of Copenhagen, Denmark.

出版信息

J Assist Reprod Genet. 1997 Nov;14(10):581-8. doi: 10.1023/a:1022528617732.

DOI:10.1023/a:1022528617732
PMID:9447458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3454735/
Abstract

PURPOSE

The possible effects of circulating FSH levels as used during IVF treatment on oocyte maturation and subsequent preembryo development were evaluated.

METHODS

Serum levels of FSH and LH on days 1 and 8 of ovarian stimulation and on the day of oocyte retrieval (OR) were correlated with subsequent preembryo development in vitro. After pituitary downregulation, 244 normogonadotropic women followed a fixed protocol for the first 7 days of stimulation.

RESULTS

The average FSH concentration on day 8 of stimulation was 11.5 IU/L and exceeded the expected midcycle surge of FSH by more than 25%. In contrast, levels of LH were below an average of 2 IU/L throughout the stimulation period. The concentration of FSH on day 8 and on the day of OR showed a significant inverse correlation with cleavage rate, whereas levels of LH, age, and body mass index showed no such correlation.

CONCLUSIONS

Supraphysiologic levels of FSH seems to affect oocyte maturation negatively. Premature resumption of meiosis, leading to retrieval of postmature oocytes with a reduced developmental potential, is suggested as the underlying mechanism.

摘要

目的

评估体外受精（IVF）治疗期间使用的循环卵泡刺激素（FSH）水平对卵母细胞成熟及随后的胚胎前期发育的可能影响。

方法

将卵巢刺激第1天和第8天以及取卵日（OR）时的FSH和LH血清水平与随后的体外胚胎前期发育进行关联分析。垂体降调节后，244名性腺功能正常的女性在刺激的前7天遵循固定方案。

结果

刺激第8天的平均FSH浓度为11.5 IU/L，超过预期的FSH中期峰值超过25%。相比之下，整个刺激期LH水平低于平均2 IU/L。第8天和取卵日的FSH浓度与卵裂率呈显著负相关，而LH水平、年龄和体重指数则无此相关性。

结论

超生理水平的FSH似乎对卵母细胞成熟有负面影响。减数分裂过早恢复，导致取出具有降低发育潜能的过熟卵母细胞，被认为是潜在机制。