Metcalf P A, Scragg R K, Dryson E
Department of Statistics, University of Auckland, New Zealand.
Int J Obes Relat Metab Disord. 1997 Mar;21(3):203-10. doi: 10.1038/sj.ijo.0800388.
To examine the relationship between albuminuria and measures of body morphology.
Cross-sectional study of European, Maori and Pacific Island workers aged 40 y and over.
3960 non-diabetic, non-hypertensive, non-lipidaemic, non-proteinuric middle-aged men and women.
Height, weight, waist, hip, fasting and 2 h glucose, systolic and diastolic blood pressure, urinary creatinine and urinary albumin measurements.
After adjusting for age and gender, the relative risks (95% confidence interval) of microalbuminuria were 4.87-fold (3.10-7.64) higher in Maori, and 4.96-fold (3.40-7.24) higher in Pacific Islanders compared to European New Zealanders. In contrast, age and gender adjusted relative risks (95% confidence interval) for high albumin:creatinine ratios were 6.38 (4.27, 9.53) in Maori and 5.14 (3.54, 7.48) in Pacific Islanders compared to European workers. Workers with microalbuminuria had higher urinary creatinine concentrations than those with urinary albumin in the normal range. Age and gender adjusted partial correlation coefficients between urinary albumin concentrations and the inverse of urinary creatinine concentrations were highest in European and Maori workers. Apart from Pacific islanders, urinary creatinine concentrations accounted for over 20% of the variation in urinary albumin concentrations in healthy individuals. Other independent predictors of urinary albumin concentrations were waist measurements, short stature and body mass index in Europeans and Pacific Islanders, and systolic blood pressure levels and gender in Europeans. After adjusting for age, gender, waist, height, 2 h glucose, urinary creatinine, systolic blood pressure and body mass index Maori and Pacific Islanders still had significantly higher urinary albumin concentrations than Europeans.
Urinary creatinine concentrations were significantly associated with urinary albumin concentrations in all ethnic groups, and, with the exception of Pacific Islanders, accounted for a large proportion of the variation in urinary albumin concentrations in healthy individuals. Urinary albumin concentrations were associated with measures of obesity and short stature in Europeans and Pacific Islanders, and systolic blood pressure levels and gender in Europeans. However, measures of body morphology did not completely explain the higher urinary albumin concentrations in Maori or Pacific Islanders.
研究蛋白尿与身体形态测量指标之间的关系。
对年龄在40岁及以上的欧洲、毛利和太平洋岛民工人进行横断面研究。
3960名非糖尿病、非高血压、非血脂异常、无蛋白尿的中年男性和女性。
身高、体重、腰围、臀围、空腹及餐后2小时血糖、收缩压和舒张压、尿肌酐及尿白蛋白测量值。
在对年龄和性别进行校正后，与欧洲裔新西兰人相比，毛利人微量白蛋白尿的相对风险（95%置信区间）高4.87倍（3.10 - 7.64），太平洋岛民高4.96倍（3.40 - 7.24）。相比之下，与欧洲工人相比，校正年龄和性别后的高白蛋白：肌酐比值的相对风险（95%置信区间）在毛利人为6.38（4.27，9.53），在太平洋岛民为5.14（3.54，7.48）。微量白蛋白尿患者的尿肌酐浓度高于尿白蛋白在正常范围内的患者。在欧洲和毛利工人中，校正年龄和性别后的尿白蛋白浓度与尿肌酐浓度倒数之间的偏相关系数最高。除太平洋岛民外，健康个体中尿肌酐浓度占尿白蛋白浓度变异的20%以上。尿白蛋白浓度的其他独立预测因素在欧洲人和太平洋岛民中为腰围测量值、身材矮小和体重指数，在欧洲人中为收缩压水平和性别。在对年龄、性别、腰围、身高、餐后2小时血糖、尿肌酐、收缩压和体重指数进行校正后，毛利人和太平洋岛民的尿白蛋白浓度仍显著高于欧洲人。
尿肌酐浓度在所有种族中均与尿白蛋白浓度显著相关，除太平洋岛民外，在健康个体中占尿白蛋白浓度变异的很大比例。欧洲人和太平洋岛民的尿白蛋白浓度与肥胖和身材矮小测量指标相关，欧洲人的尿白蛋白浓度与收缩压水平和性别相关。然而，身体形态测量指标并不能完全解释毛利人或太平洋岛民较高的尿白蛋白浓度。
