Richardson D A, Bexton R S, Shaw F E, Kenny R A
Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
Pacing Clin Electrophysiol. 1997 Mar;20(3 Pt 2):820-3. doi: 10.1111/j.1540-8159.1997.tb03912.x.
To study the prevalence of Cardioinhibitory Carotid Sinus Hypersensitivity (CICSH) in patients 50 years or over presenting to casualty with "unexplained" or "recurrent" falls. The prospective study was from October 1, 1995 to April 30, 1996 in the Inner City Accident and Emergency Departments, Newcastle Upon Tyne, U.K. Ten thousand four hundred forty-three patients 50 years and over presented, of which 4,051 (39%) were fallers. Fallers were excluded if they lived over 15 miles from the hospital (81), were registered blind (17), were unable to speak English (22), were unable to previously walk (27), if there was a history of only one accidental fall (1,659) or were cognitively impaired (776: Mini Mental State Examination < 24 [30]) or if there was a clear attributable medical diagnosis for the fall (871). Five hundred ninety-eight "unexplained" or "recurrent" fallers (defined as three or more falls in the previous 12 months) were assessed for carotid sinus massage (CSM). One hundred forty-five patients declined CSM (24%), 70 (12%) had relative contraindications to CSM and 13 already had pacemakers in situ (2%). Two hundred seventy-nine underwent CSM, of whom 65 had CICSH (23%), which might be amenable to treatment with pacemakers. The prevalence of CICSH (a potentially treatable condition) in "unexplained" or "recurrent" fallers who present to the accident and emergency department is 23%. A randomized control study to assess benefit from pacemaker intervention in these patients is underway.
研究50岁及以上因“不明原因”或“反复”跌倒而到急诊就诊患者中,心脏抑制型颈动脉窦过敏症(CICSH)的患病率。该前瞻性研究于1995年10月1日至1996年4月30日在英国泰恩河畔纽卡斯尔市中心区的事故与急诊科进行。共有10443名50岁及以上患者前来就诊,其中4051名(39%)为跌倒患者。如果跌倒患者居住在距离医院超过15英里处(81例)、登记为盲人(17例)、不会说英语(22例)、之前无法行走(27例)、仅有一次意外跌倒史(1659例)、认知功能受损(776例:简易精神状态检查表评分<24分[满分30分])或跌倒有明确可归因的医学诊断(871例),则将其排除。对598名“不明原因”或“反复”跌倒患者(定义为在过去12个月内跌倒3次或更多次)进行了颈动脉窦按摩(CSM)评估。145名患者拒绝接受CSM(24%),70名(12%)有CSM的相对禁忌症,13名(2%)已植入起搏器。279名患者接受了CSM,其中65名患有CICSH(23%),这可能适合用起搏器治疗。在到事故与急诊科就诊的“不明原因”或“反复”跌倒患者中,CICSH(一种潜在可治疗的疾病)的患病率为23%。一项评估起搏器干预对这些患者益处的随机对照研究正在进行中。