Barr C E, Qureshi M N, Qiu Z, Kaim J, Zhang W
Department of Dental Medicine, Beth Israel Medical Center, New York 10003, USA.
Oral Dis. 1996 Sep;2(3):198-201. doi: 10.1111/j.1601-0825.1996.tb00224.x.
To determine whether a significant association occurs between the presence of various periodontal diseases and recoverable infectious HIV-I in the saliva of injecting drug users.
Five hundred and fifty-one injecting drug users were recruited from various programs associated with the Beth Israel Medical Center. Examiners were 'blinded' to the subject's HIV-I serostatus. A socio-economic and risk factors' survey was conducted and a complete oral examination, including periodontal disease indices was performed. Whole saliva and blood were collected for virus culture.
Recovery of infectious HIV-I in saliva related to presence of periodontal diseases.
Those HIV-I seropositive subjects with periodontal diseases did not differ from those HIV-I seropositive subjects without periodontal disease in mean age and immune status. Less than 1% of the HIV-I seropositive subjects had cultivable HIV-I in their saliva while it was present in 78% of PBMCs and 35% of the sera. There was no significant association between infectious HIV-I in saliva, serum, or PBMCs and any of the various periodontal diseases.
The presence of periodontal disease in HIV-I seropositive injecting drug users does not appear to be a potential risk factor for infectious HIV-I in saliva, probably due to the various anti-viral components of saliva.
确定在注射吸毒者的唾液中，各种牙周疾病的存在与可检测到的传染性HIV-1之间是否存在显著关联。
从与贝斯以色列医疗中心相关的各种项目中招募了551名注射吸毒者。检查人员对受试者的HIV-1血清学状态“不知情”。进行了社会经济和风险因素调查，并进行了包括牙周疾病指数在内的全面口腔检查。采集全唾液和血液用于病毒培养。
唾液中与牙周疾病存在相关的传染性HIV-1的检测。
患有牙周疾病的HIV-1血清阳性受试者与未患牙周疾病的HIV-1血清阳性受试者在平均年龄和免疫状态方面没有差异。不到1%的HIV-1血清阳性受试者唾液中可培养出HIV-1，而在78%的外周血单核细胞和35%的血清中可检测到。唾液、血清或外周血单核细胞中的传染性HIV-1与任何一种牙周疾病之间均无显著关联。
HIV-1血清阳性的注射吸毒者中牙周疾病的存在似乎不是唾液中传染性HIV-1的潜在危险因素，这可能是由于唾液中的各种抗病毒成分所致。
