Radulovacki M, Trbovic S, Carley D W
Department of Pharmacology (M/C 868), College of Medicine, University of Illinois at Chicago 60612, USA.
Sleep. 1996 Dec;19(10):767-73. doi: 10.1093/sleep/19.10.767.
The effects of hypotension and obesity on spontaneous apnea (SA) and post-sigh sleep apnea (PSA) were studied in Zucker rats by monitoring blood pressure, respiration, and sleep state for 6 hours. Hypotension produced by intraperitoneal administration of hydralazine (2 mg/kg) was associated with reduced SA and PSA expression in nonrapid eye movement sleep in both lean and obese rats. In both animal groups, hypotension reduced rapid eye movement (REM) sleep by 50% but exerted no significant effect on REM-related expression of SA. Blood pressure lowering also correlated with increased respiratory rate and inspired minute ventilation during sleep, suggesting that the effects of hypotension on apnea expression may arrive via modulation of respiratory drive. These findings emphasize the interdependence of cardiorespiratory functions and may have implications regarding the mechanisms of central apnea in man.
通过监测血压、呼吸和睡眠状态6小时，研究了低血压和肥胖对Zucker大鼠自发性呼吸暂停（SA）和叹息后睡眠呼吸暂停（PSA）的影响。腹腔注射肼屈嗪（2mg/kg）所致的低血压与瘦型和肥胖型大鼠非快速眼动睡眠中SA和PSA表达的降低有关。在两组动物中，低血压使快速眼动（REM）睡眠减少50%，但对与REM相关的SA表达无显著影响。血压降低还与睡眠期间呼吸频率增加和吸入分钟通气量增加相关，提示低血压对呼吸暂停表达的影响可能通过调节呼吸驱动实现。这些发现强调了心肺功能的相互依存性，可能对人类中枢性呼吸暂停的机制具有启示意义。
