Dörner I, Brunner H, Schiefer H G, Loos M, Wellensiek H J
Infect Immun. 1977 Oct;18(1):1-7. doi: 10.1128/iai.18.1.1-7.1977.
Acholeplasma laidlawii is killed and lysed by fresh normal guinea pig serum (GPS) without additional antibodies. Prior incubation of GPS with whole A. laidlawii organisms abolishes the killing activity of GPS. In the present study it was demonstrated that antibodies are present in normal GPS. The classical pathway, not the alternative pathway, of the complement sequence was activated by these antibodies in fresh normal GPS. The antibodies in GPS belong to the IgG class of immunoglobulins. They are directed predominantly against the membrane phospholipids of A. laidlawii. These antibodies may be induced either by natural infection of guinea pigs with A. laidlawii or by antigenic determinants of other microorganisms of food antigens.
莱氏无胆甾原体可被新鲜的正常豚鼠血清（GPS）杀死并裂解，无需额外抗体。将GPS与完整的莱氏无胆甾原体生物预先孵育会消除GPS的杀伤活性。在本研究中，证明正常GPS中存在抗体。新鲜正常GPS中的这些抗体激活了补体序列的经典途径，而非替代途径。GPS中的抗体属于免疫球蛋白的IgG类。它们主要针对莱氏无胆甾原体的膜磷脂。这些抗体可能是由豚鼠自然感染莱氏无胆甾原体或由其他微生物或食物抗原的抗原决定簇诱导产生的。
