尿素水解以及副溶血性弧菌热稳定直接溶血素（TDH）的产生受抑制，这与TDH相关溶血素基因的存在有关。
Urea hydrolysis and suppressed production of thermostable direct hemolysin (TDH) by Vibrio parahaemolyticus associated with presence of TDH-related hemolysin genes.
作者信息
Okitsu T, Osawa R, Pornruangwong S, Yamai S
机构信息
Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratories, 1-1-1 Nakao, Asahi-ku, Yokohama-shi, Kanagawa, 241, Japan.
出版信息
Curr Microbiol. 1997 May;34(5):314-7. doi: 10.1007/s002849900188.
A total of 18 strains of V. parahaemolyticus isolated from patients of past food poisoning cases occurring in Kanagawa Prefecture, Japan, were assayed for presence of the thermostable direct hemolysin (TDH) gene and the TDH-related hemolysin (TRH) genes (trh 1 and trh 2) with specific reference to their ability to hydrolyze urea and TDH production. A polymerase chain reaction assay revealed that all urea-hydrolyzing strains (9 strains) carried either trh 1 gene or trh 2 gene. The strains carrying the trh genes as well as the tdh gene produced TDH less by a factor of 4 to 16 than those carrying only the tdh gene, suggesting the expression of the tdh gene was suppressed by the presence of trh gene through a mechanism yet to be defined.
对从日本神奈川县过去食物中毒病例患者中分离出的总共18株副溶血性弧菌进行了检测，以确定其是否存在耐热直接溶血素（TDH）基因以及TDH相关溶血素（TRH）基因（trh 1和trh 2），并特别参考了它们水解尿素的能力和TDH的产生情况。聚合酶链反应检测显示，所有尿素水解菌株（9株）都携带trh 1基因或trh 2基因。携带trh基因以及tdh基因的菌株产生的TDH比仅携带tdh基因的菌株少4至16倍，这表明trh基因的存在通过一种尚未明确的机制抑制了tdh基因的表达。
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