Ebringer R, Cooke D, Cawdell D R, Cowling P, Ebringer A
Rheumatol Rehabil. 1977 Aug;16(3):190-6. doi: 10.1093/rheumatology/16.3.190.
A search for the presence of Klebsiella-Enterobacter spp. and Yersinia enterocolitica in urine and faeces of 63 patients with ankylosing spondylitis was conducted because these microorganisms have been demonstrated to cross-react immunologically with HL-A B27 positive lymphocytes. The patients were graded into three groups on the basis of disease activity. Klebsiella spp. were found in the faeces of 13 (93%) of the 14 patients with 'active' disease, 10 (48%) of the 21 patients with 'probably active' disease and in one (4%) of the 28 patients with 'inactive' disease. Positive cultures were also obtained in 47 (38%) of 124 controls. It is suggested that the presence of Klebsiella spp. in faecal cultures may be associated with 'active' disease in patients with ankylosing spondylitis.
对63例强直性脊柱炎患者的尿液和粪便进行了肺炎克雷伯菌-肠杆菌属和小肠结肠炎耶尔森菌检测，因为这些微生物已被证明可与HL-A B27阳性淋巴细胞发生免疫交叉反应。根据疾病活动度将患者分为三组。在14例“活动期”疾病患者中的13例（93%）粪便中发现了克雷伯菌属，21例“可能活动期”疾病患者中的10例（48%）以及28例“非活动期”疾病患者中的1例（4%）粪便中发现了克雷伯菌属。在124名对照者中，也有47例（38%）培养结果呈阳性。提示粪便培养中克雷伯菌属的存在可能与强直性脊柱炎患者的“活动期”疾病有关。
