Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Department of Immunology and Microbiology, Institution of Laboratory Medicine of Changshu, Changshu, Jiangsu 215500, People's Republic of China.
Int J Nanomedicine. 2019 Oct 29;14:8521-8542. doi: 10.2147/IJN.S216199. eCollection 2019.
Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage-bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward.
强直性脊柱炎（AS）是一种以软骨-骨界面炎症和强直为特征的复杂疾病。该病在年轻男性中更为常见，其危险因素包括遗传和环境因素。虽然 AS 的发病机制尚不完全清楚，但它被认为是一种免疫介导的疾病，涉及炎症细胞浸润和人类白细胞抗原-B27。目前，尚无针对这种疾病的特定诊断技术；因此，通常采用临床症状、实验室检查和影像学技术等传统诊断方法。已经发表了许多关于传统治疗方法的综述论文，在这项综述工作中，我们专注于更有前途的基于纳米医学的治疗方法，以推动该领域的发展。
