Krivorutchenko Iu L, Andronovskaia I B, Chirva V Ia, Pertel' S S, Grishkovets V I, Zemliakov A E, Kur'ianov V O, Krivoshein Iu S
Vopr Virusol. 1997 Jan-Feb;42(1):34-6.
The effects of muramyldipeptide (MDP), several new MDP derivatives, and saponins derived from Hedera taurica Carr, on the in vitro replication of HIV-1 were studied. The coefficient of alteration of the rate of HIV replication was used to compare these reagents' effects on virus replication in Jurkat-tat cells. This coefficient was calculated as the ratio of concentrations of HIV p24 in supernatants to the amount of viable cells. Muramylpeptides boosted HIV replication. Only one modified muramylpeptide alpha-butyl-MDP and tauroside H2 were not capable of boosting HIV-1 antigen production.
研究了胞壁酰二肽（MDP）、几种新型MDP衍生物以及来自高加索常春藤的皂苷对HIV-1体外复制的影响。使用HIV复制速率的改变系数来比较这些试剂对Jurkat-tat细胞中病毒复制的影响。该系数计算为上清液中HIV p24浓度与活细胞数量的比值。胞壁酰肽促进了HIV复制。只有一种修饰的胞壁酰肽α-丁基-MDP和牛磺糖苷H2不能促进HIV-1抗原的产生。
