Mehmetçik G, Toker G, Uysal M
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Horm Metab Res. 1997 Feb;29(2):63-5. doi: 10.1055/s-2007-978987.
Endogenous malondialdehyde and diene conjugate levels were increased in hypercholesterolemic subjects with serum cholesterol levels above 240 mg/dl as compared to normocholesterolemic subjects (below 20 mg/dl). A decrease in vitamin E/cholesterol and vitamin C/cholesterol ratios was observed in serum of hypercholesterolemic individuals. However, the susceptibility of serum to copper-induced lipid peroxidation and antioxidant activity were found unchanged. The present study indicates that hypercholesterolemic subjects have a high level of circulating lipid peroxides and that a higher tendency towards atherosclerosis in these subjects may be related to increased baseline levels of serum lipid peroxides.
