Mueck A O, Seeger H, Kasspohl-Butz S, Teichmann A T, Lippert T H
Department Obstetrics and Gynecology, University Tübingen, Germany.
Horm Metab Res. 1997 Feb;29(2):80-3. doi: 10.1055/s-2007-978991.
Previous studies have shown that estradiol increases urinary excretion of the main stable metabolite of serotonin, 5-hydroxyindole acetic acid (5-HIAA), reflecting an increase in serotonin production. In the present study, the effect of the progestin norethisterone acetate (NETA) on serotonin metabolism was investigated, both alone and in addition to estradiol replacement in 20 postmenopausal women. Urinary excretion of 5-HIAA was measured after treatment with NETA orally for 8 days, estradiol valerate orally for 9 days and a combination of both hormones for 12 days. 5-HIAA values, expressed as percentages of the pretreatment values, were significantly increased only after the estrogen treatment phase. NETA alone did not significantly alter the serotonin metabolite excretion; in combination with estradiol, the estradiol effect on serotonin metabolism was abolished. This indicates that adding norethisterone acetate to estradiol replacement therapy may have a negative impact on the effect of estradiol on serotonin metabolism.
先前的研究表明，雌二醇会增加血清素主要稳定代谢产物5-羟吲哚乙酸（5-HIAA）的尿排泄量，这反映出血清素生成增加。在本研究中，研究了孕激素醋酸炔诺酮（NETA）对血清素代谢的影响，该研究在20名绝经后女性中单独进行，以及在雌二醇替代治疗的基础上进行。口服NETA 8天、戊酸雌二醇9天以及两种激素联合使用12天后，测量5-HIAA的尿排泄量。以治疗前值的百分比表示的5-HIAA值仅在雌激素治疗阶段后显著增加。单独使用NETA并没有显著改变血清素代谢产物的排泄；与雌二醇联合使用时，雌二醇对血清素代谢的作用被消除。这表明在雌二醇替代治疗中添加醋酸炔诺酮可能会对雌二醇对血清素代谢的作用产生负面影响。
