de Pedro N, Alonso-Gómez A L, Gancedo B, Valenciano A I, Delgado M J, Alonso-Bedate M
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
Behav Neurosci. 1997 Apr;111(2):398-403. doi: 10.1037//0735-7044.111.2.398.
The anoretic effect of corticotropin-releasing factor (CRF) was not dependent on adrenal activation in goldfish (Carassius auratus). Moreover, an interaction between CRF and the hypothalamic catecholaminergic system in the central regulation of food intake was observed. The intracerebroventricular (icv) administration of CRF increased cortisol levels and reduced food intake and hypothalamic norepinephrine and dopamine content at 2 hr postinjection, with these effects reversed by alpha-helical CRF[9-41] pretreatment. The anoretic effect of CRF was independent of the circulating cortisol increase, because it was only evoked after icv injections but not after intraperitoneal (ip) administration. Furthermore, the increase in plasma cortisol levels induced by ip administration of this steroid did not modify feeding.
促肾上腺皮质激素释放因子（CRF）对金鱼（Carassius auratus）的厌食作用并不依赖于肾上腺激活。此外，还观察到CRF与下丘脑儿茶酚胺能系统在食物摄入的中枢调节中存在相互作用。脑室注射（icv）CRF可使皮质醇水平升高，并在注射后2小时降低食物摄入量以及下丘脑去甲肾上腺素和多巴胺含量，而α-螺旋CRF[9-41]预处理可逆转这些作用。CRF的厌食作用与循环皮质醇的增加无关，因为它仅在icv注射后诱发，而在腹腔注射（ip）后不会诱发。此外，腹腔注射这种类固醇所诱导的血浆皮质醇水平升高并不会改变摄食情况。
