Hubinger L, Mackinnon L T, Barber L, McCosker J, Howard A, Lepre F
Department of Human Movement Studies, University of Queensland, Australia.
Med Sci Sports Exerc. 1997 Apr;29(4):436-42. doi: 10.1097/00005768-199704000-00003.
This investigation examined the acute response of serum lipoprotein(a) (Lp(a)) concentration immediately after, and during several days following, level and downhill motorized treadmill running. Eight males ran for 1 h on a level motorized treadmill at an intensity producing 90% maximum heart rate (MHR). On a separate occasion, three males and three females performed downhill (negative 13.4% incline) treadmill running at an intensity producing 75-80% MHR. For both protocols, serial blood samples were taken pre- and post-exercise and at the same time of day 1, 3, 5, and 7 days following exercise. Levels of Lp(a), creatine kinase (CK), C-reactive protein (CRP), and ferritin were measured. Repeated measures statistical analysis (Friedman ANOVA) showed no significant change in the median level of Lp(a) (level run, 5.0 mg.dl-1; downhill run, 7.45 mg.dl-1) across time following either protocol. After level running, ferritin levels 5 and 7 d post-exercise were significantly (P < 0.05) lower compared with immediately and 1 d post-exercise measures (Friedman ANOVA). Following level running, the Wilcoxon signed rank test showed significant (P < 0.05) elevations in CK levels immediately, 1 and 5 d post-exercise compared with pre-exercise values. Following downhill running. CK level was significantly elevated up to 3 d post-exercise (Wilcoxon signed rank). Calculated plasma volume did not change significantly following either protocol. These data suggest that Lp(a) does not change acutely in response to level or downhill treadmill running up to 60 min duration.
本研究调查了在进行水平和下坡电动跑步机跑步后即刻以及随后几天内血清脂蛋白(a) [Lp(a)] 浓度的急性反应。八名男性在水平电动跑步机上以产生90%最大心率（MHR）的强度跑1小时。在另一次测试中，三名男性和三名女性以产生75 - 80% MHR的强度进行下坡（坡度为负13.4%）跑步机跑步。对于这两种方案，在运动前和运动后以及运动后第1、3、5和7天的同一时间采集系列血样。测量Lp(a)、肌酸激酶（CK）、C反应蛋白（CRP）和铁蛋白水平。重复测量统计分析（Friedman方差分析）表明，在任一方案后的不同时间点，Lp(a)的中位数水平（水平跑时为5.0 mg·dl⁻¹；下坡跑时为7.45 mg·dl⁻¹）均无显著变化。水平跑步后，与运动后即刻和第1天的测量值相比，运动后第5天和第7天的铁蛋白水平显著降低（P < 0.05）（Friedman方差分析）。水平跑步后，Wilcoxon符号秩检验显示，与运动前值相比，运动后即刻、第1天和第5天的CK水平显著升高（P < 0.05）。下坡跑步后，CK水平在运动后3天内显著升高（Wilcoxon符号秩检验）。两种方案后计算的血浆量均无显著变化。这些数据表明，长达60分钟的水平或下坡跑步机跑步不会使Lp(a)产生急性变化。
