Tello-Montoliu Antonio, Roldán Vanessa, Climent Vicente E, Sogorb Francisco, Lip Gregory Y H, Marín Francisco
Cardiology Department, Hospital General Universitario, Alicante, Spain.
J Thromb Thrombolysis. 2006 Apr;21(2):163-6. doi: 10.1007/s11239-006-4384-4.
Exercise has been reported to simultaneously trigger and protect against sudden death, the so-called "The Paradox of Exercise". Differences in fibrinolytic function appear to exist between chronic and acute exercise. The aim of the present study was to assess the fibrinolytic system after strenuous exercise in healthy people and explored the influence of smoking habit.
23 healthy male volunteers were studied (14 non-smokers; 9 current smokers). Citrated plasma blood samples were taken before and 30 minutes after a maximal exercise treadmill test, and levels of tissue type plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PAI-1) antigen and lipoprotein-a, Lp(a), [all ELISA] were measured as indices of fibrinolytic function.
Smokers had higher body mass index and higher heart rate at baseline than non smokers (p = 0.046 and p = 0.001, respectively). At baseline, smokers showed increased plasma Lp(a) levels than non smokers (p = 0.04), with no differences in t-PA and PAI-1 antigen levels. Following the exercise treadmill test, smokers had a shorter exercise duration and lower exercise capacity than non smokers (p = 0.008 and p = 0.004, respectively). This was associated with a reduction in t-PA antigen levels in the whole study population, (p = 0.048) without differences in PAI-1 levels, with no significant differences between smokers and non smokers. Lp(a) levels were also significantly reduced (p = 0.0001).
Acute exercise alters plasma tPA antigen and Lp(a) levels, but there was no significant effect of smoking status in healthy subjects.
据报道，运动既能引发猝死，又能预防猝死，即所谓“运动悖论”。慢性运动和急性运动的纤溶功能似乎存在差异。本研究旨在评估健康人剧烈运动后的纤溶系统，并探讨吸烟习惯的影响。
对23名健康男性志愿者进行研究（14名非吸烟者；9名当前吸烟者）。在最大运动平板试验前和试验后30分钟采集枸橼酸盐抗凝血浆血样，测量组织型纤溶酶原激活物（t-PA）抗原、纤溶酶原激活物抑制剂（PAI-1）抗原和脂蛋白-a（Lp(a)）[均采用酶联免疫吸附测定法]的水平，作为纤溶功能指标。
吸烟者在基线时的体重指数和心率高于非吸烟者（分别为p = 0.046和p = 0.001）。基线时，吸烟者的血浆Lp(a)水平高于非吸烟者（p = 0.04），t-PA和PAI-1抗原水平无差异。运动平板试验后，吸烟者的运动持续时间比非吸烟者短，运动能力也低于非吸烟者（分别为p = 0.008和p = 0.004）。这与整个研究人群中t-PA抗原水平的降低有关（p = 0.048），PAI-1水平无差异，吸烟者和非吸烟者之间也无显著差异。Lp(a)水平也显著降低（p = 0.0001）。
急性运动可改变血浆tPA抗原和Lp(a)水平，但吸烟状况对健康受试者无显著影响。
