Aisen M L, Krebs H I, Hogan N, McDowell F, Volpe B T
Burke Rehabilitation Hospital, White Plains, NY, USA.
Arch Neurol. 1997 Apr;54(4):443-6. doi: 10.1001/archneur.1997.00550160075019.
We used MIT-Manus, a robot designed to provide interactive, goal-directed motor activity for clinical neurologic applications.
To test whether this robotic manipulation of the impaired limb influenced motor recovery in patients with hemiplegia.
Sequential patients with a history of a single stroke and hemiplegia (N = 20) hospitalized on the same acute care rehabilitation floor were enrolled in a standard rehabilitation program supplemented by either robot-aided therapy or sham robot-aided therapy. These 2 groups were comparable in age, initial physical impairment, and time between onset of the stroke and enrollment in the trial. Patients, clinical team members, and the clinical evaluator were blinded to the treatment group assignments. Standardized assessment tools measured outcomes.
Impairment and disability declined in both groups between hospital admission and discharge. The robot-treated group showed a greater degree of improvement in all 3 measures of motor recovery, and the change in motor status measured in the proximal upper limb musculature was significant (P = .002). No adverse events resulted from robot-assisted therapy.
These results suggest that robotic manipulation of the impaired limb may favorably add to recovery following stroke and that robotics may provide new strategies for neurologic rehabilitation.
我们使用了麻省理工学院的手部机器人（MIT-Manus），这是一种为临床神经学应用设计的、能够提供交互式目标导向运动活动的机器人。
测试对偏瘫患者受损肢体进行这种机器人操作是否会影响运动恢复。
将在同一急性护理康复楼层住院的、有单次中风和偏瘫病史的连续患者（N = 20）纳入一个标准康复计划，该计划辅以机器人辅助治疗或假机器人辅助治疗。这两组在年龄、初始身体损伤以及中风发作与纳入试验之间的时间方面具有可比性。患者、临床团队成员和临床评估人员对治疗组分配情况不知情。使用标准化评估工具测量结果。
两组患者从入院到出院时，损伤和残疾程度均有所下降。机器人治疗组在所有三项运动恢复指标上均显示出更大程度的改善，并且在近端上肢肌肉组织中测量的运动状态变化具有显著性（P = 0.002）。机器人辅助治疗未导致任何不良事件。
这些结果表明，对受损肢体进行机器人操作可能会对中风后的恢复产生有利影响，并且机器人技术可能为神经康复提供新的策略。
