一名患有XYY综合征的青少年患小无裂细胞淋巴瘤。

Small noncleaved cell lymphoma in an adolescent with the XYY syndrome.

作者信息

Sandlund J T, Raimondi S C

机构信息

Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101, USA.

出版信息

Cancer Genet Cytogenet. 1997 Apr;94(2):88-90. doi: 10.1016/s0165-4608(96)00201-4.

DOI:10.1016/s0165-4608(96)00201-4

PMID:9109933

Abstract

A 19-year-old male was diagnosed with stage III abdominal small noncleaved cell (SNCC) non-Hodgkin lymphoma (NHL). Cytogenetic evaluation of the tumor revealed a complex karyotype which included the t(8;14)(q24;q32), classically associated with this lymphoma histotype, and an extra Y chromosome. After remission was obtained, cytogenetic analysis of bone marrow cells and PHA-stimulated peripheral blood lymphocytes disclosed a normal karyotype except for the persistence of an extra Y chromosome, diagnostic of the XYY syndrome. This is the first reported case of SNCC NHL in an adolescent with the XYY syndrome.

摘要

一名19岁男性被诊断为Ⅲ期腹部小无裂细胞（SNCC）非霍奇金淋巴瘤（NHL）。对肿瘤进行的细胞遗传学评估显示其核型复杂，其中包括经典上与这种淋巴瘤组织学类型相关的t(8;14)(q24;q32)，以及一条额外的Y染色体。在获得缓解后，对骨髓细胞和PHA刺激的外周血淋巴细胞进行的细胞遗传学分析显示，除了持续存在一条额外的Y染色体外，核型正常，诊断为XYY综合征。这是首例报道的患有XYY综合征的青少年SNCC NHL病例。