Martin M U, Falk W
Medical School Hannover, Germany.
Eur Cytokine Netw. 1997 Mar;8(1):5-17.
The aim of this mini-review is to give an update on the current developments concerning the IL-1 plasma membrane receptor complex and the modes of signal transduction through the plasma membrane. The mechanisms of signal generation at the cytosolic side of the plasma membrane will be summarized. Possible coupling mechanisms to down-stream signalling elements will be discussed, which result in the complex activation of transcription factors responsible for the cellular responses to IL-1. It is not the aim of this review to extensively summarize IL-1 induced cytosolic kinase cascades and activation of transcription factors.
本综述的目的是介绍白细胞介素-1（IL-1）质膜受体复合物的当前进展以及通过质膜进行信号转导的模式。将总结质膜胞质侧信号产生的机制。还将讨论与下游信号元件的可能偶联机制，这些机制导致负责细胞对IL-1反应的转录因子的复杂激活。本综述的目的并非广泛总结IL-1诱导的胞质激酶级联反应和转录因子的激活。
