化学诱变：一个新出现的公共卫生问题。
Chemical mutagenesis: an emerging issue for public health.
作者信息
Claxton L D, Barry P Z
出版信息
Am J Public Health. 1977 Nov;67(11):1037-42. doi: 10.2105/ajph.67.11.1037.
Abstract
Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed.
摘要
化学诱变剂在环境中普遍存在，被认为是对后代健康的潜在威胁。本文概述了化学诱变作为一个公共卫生问题的情况。讨论了确定对人类群体风险时的几个问题，包括将科学数据外推至人类的困难、接触与可识别的基因损伤之间的潜伏期，以及必须检测的大量化学物质。还描述了测试系统。讨论了通过联邦法规进行控制的可能性。
相似文献
1
Chemical mutagenesis: an emerging issue for public health.化学诱变：一个新出现的公共卫生问题。
Am J Public Health. 1977 Nov;67(11):1037-42. doi: 10.2105/ajph.67.11.1037.
2
Public health hazards from environmental chemical carcinogens, mutagens and teratogens.环境化学致癌物、诱变剂和致畸剂对公众健康的危害。
Health Phys. 1971 Nov;21(5):689-707. doi: 10.1097/00004032-197111000-00010.
3
[Evaluation of the embryotoxic risk of industrial chemicals in pregnancy].[孕期工业化学品胚胎毒性风险评估]
Geburtshilfe Frauenheilkd. 1986 Jun;46(6):335-9. doi: 10.1055/s-2008-1035926.
4
Extending the threshold of regulation concept: de minimis limits for carcinogens and mutagens.扩展监管概念的阈值：致癌物和诱变剂的微量豁免限度
Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):209-16. doi: 10.1006/rtph.2002.1534.
5
[Environmental mutagenesis].
Orv Hetil. 1993 Jun 13;134(24):1291-6.
6
Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.
Scand J Work Environ Health. 1979 Dec;5(4):307-27. doi: 10.5271/sjweh.2651.
7
8
Environmental pathology. A review.环境病理学。综述。
Am J Pathol. 1972 Feb;66(2):352-74.
9
Methods of monitoring human exposure to carcinogenic and mutagenic agents.监测人类接触致癌和致突变剂的方法。
IARC Sci Publ. 1984(59):423-7.
10
Guidelines for the testing of chemical for mutagenicity. Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment.
Rep Health Soc Subj (Lond). 1981;24:1-95.
本文引用的文献
1
Angiosarcoma of liver in the manufacture of polyvinyl chloride.氯乙烯制造过程中发生的肝血管肉瘤。
J Occup Med. 1974 Mar;16(3):150-1.
2
The three-tier approach to mutagenicity screening and the concept of radiation-equivalent dose.致突变性筛查的三层方法及辐射当量剂量的概念。
Mutat Res. 1974 Aug;26(4):335-40. doi: 10.1016/s0027-5107(74)80031-x.
3
Editorial: AF-2--food preservative or genetic hazard?
Mutat Res. 1974 Feb;26(1):1-2.
4
A tier system approach to mutagen testing.一种用于诱变试验的分级系统方法。
Mutat Res. 1974 Aug;26(4):329-33. doi: 10.1016/s0027-5107(74)80030-8.
5
An improved bacterial test system for the detection and classification of mutagens and carcinogens.一种用于检测诱变剂和致癌物并对其进行分类的改良细菌检测系统。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6. doi: 10.1073/pnas.70.3.782.
6
Occupational disease among operating room personnel: a national study. Report of an Ad Hoc Committee on the Effect of Trace Anesthetics on the Health of Operating Room Personnel, American Society of Anesthesiologists.手术室工作人员的职业病：一项全国性研究。美国麻醉医师协会微量麻醉剂对手术室工作人员健康影响特设委员会的报告。
Anesthesiology. 1974 Oct;41(4):321-40.
7
Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells.
Mutat Res. 1974 Aug;26(4):307-18. doi: 10.1016/s0027-5107(74)80028-x.
8
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.染发剂具有致突变性：多种致突变成分的鉴定。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2423-7. doi: 10.1073/pnas.72.6.2423.
9
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.在沙门氏菌/微粒体试验中作为诱变剂的致癌物检测：300种化学物质的测定
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9. doi: 10.1073/pnas.72.12.5135.
10
Identification of Haemoglobin S in red cells and normoblasts, using fluorescent anti-Hb S antibodies.使用荧光抗血红蛋白S抗体鉴定红细胞和早幼红细胞中的血红蛋白S。
Br J Haematol. 1976 Sep;34(1):25-31. doi: 10.1111/j.1365-2141.1976.tb00170.x.
Zotero 插件