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化学诱变:一个新出现的公共卫生问题。

Chemical mutagenesis: an emerging issue for public health.

作者信息

Claxton L D, Barry P Z

出版信息

Am J Public Health. 1977 Nov;67(11):1037-42. doi: 10.2105/ajph.67.11.1037.

Abstract

Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed.

摘要

化学诱变剂在环境中普遍存在,被认为是对后代健康的潜在威胁。本文概述了化学诱变作为一个公共卫生问题的情况。讨论了确定对人类群体风险时的几个问题,包括将科学数据外推至人类的困难、接触与可识别的基因损伤之间的潜伏期,以及必须检测的大量化学物质。还描述了测试系统。讨论了通过联邦法规进行控制的可能性。

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A tier system approach to mutagen testing.一种用于诱变试验的分级系统方法。
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