Shah J P, Huvos A G, Strong E W
Am J Surg. 1977 Oct;134(4):531-5. doi: 10.1016/0002-9610(77)90393-2.
Only 3 per cent of all melanomas arise in the mucosa of the head and neck region. Melanomas of mucosal origin in this series differed from their cutaneous counterpart in that size of the primary lesion did not influence prognosis. Regional lymph node metastases were infrequent and did not seem to influence prognosis. Nearly all the primary lesions on microscopic review showed the presence of intralesional lymphatic and blood vessel invasion. Local recurrence at the primary site was the most common cause of treatment failure, in spite of seemingly adequate surgical resection. Surgical treatment offers long-term cure to only a limited number of patients.
所有黑色素瘤中仅有3%发生于头颈部区域的黏膜。本系列中黏膜起源的黑色素瘤与其皮肤型黑色素瘤不同，原发灶大小不影响预后。区域淋巴结转移并不常见，似乎也不影响预后。几乎所有经显微镜检查的原发灶均显示病灶内存在淋巴管和血管侵犯。尽管手术切除看似充分，但原发部位的局部复发仍是治疗失败的最常见原因。手术治疗仅能使少数患者获得长期治愈。
