Talbot A R, Herr T M, Parsons D S
ENT Department, Sydney Hospital, Australia.
Laryngoscope. 1997 Apr;107(4):500-3. doi: 10.1097/00005537-199704000-00013.
Nasal irrigations have been used for centuries without any scientific data to determine efficacy. For 10 years, the senior author has used buffered hypertonic saline nasal irrigation for patients with acute/chronic sinusitis and for those having undergone sinus surgery. A simple study was undertaken using volunteers without any significant sinonasal disease. Patients served as their own control using a saccharin clearance test before any nasal irrigation was used. Patients then used one of two solutions to irrigate their nose-buffered normal saline or buffered hypertonic saline-and were then retested. On a separate day, the control test was repeated, followed by irrigation with the alternate solution and a second saccharin clearance test. The outcome showed buffered hypertonic saline nasal irrigation to improve mucociliary transit times of saccharin, while buffered normal saline had no such effect.
几个世纪以来，人们一直在使用鼻腔冲洗法，但却没有任何科学数据来确定其疗效。十年来，资深作者一直使用缓冲高渗盐水鼻腔冲洗法来治疗急/慢性鼻窦炎患者以及接受过鼻窦手术的患者。我们对没有任何明显鼻窦疾病的志愿者进行了一项简单的研究。在使用任何鼻腔冲洗液之前，患者通过糖精清除试验作为自身对照。然后，患者使用两种溶液之一冲洗鼻腔——缓冲生理盐水或缓冲高渗盐水——之后再次进行测试。在另一天，重复对照测试，然后用另一种溶液冲洗，并进行第二次糖精清除试验。结果显示，缓冲高渗盐水鼻腔冲洗可改善糖精的黏液纤毛转运时间，而缓冲生理盐水则没有这种效果。
