Knight J A, Marrett L D
Division of Preventive Oncology, Ontario Cancer Treatment and Research Foundation, Toronto, Canada.
J Occup Environ Med. 1997 Apr;39(4):333-8. doi: 10.1097/00043764-199704000-00011.
The incidence of germ cell testicular cancer is increasing, but its etiology remains largely unknown. Initiation may occur in a parental germ cell. In a case-control study in Ontario, jobs and industries of mothers (before and during pregnancy) and fathers (before pregnancy) of 343 case subjects and 524 control subjects were analyzed. Significantly increased risk was associated with fathers who were wood processors (odds ratio [OR] = 10.46; 95% confidence interval [CI], 1.20 to 91.14), metalworkers (OR = 3.28; 95% CI, 1.03 to 10.52), stationary engineers (OR = 1.05; 95% CI, 1.05 to 11.87), or employees of the food products (OR = 2.79; 95% CI, 1.34 to 5.79), metal products (OR = 5.77, 95% CI, 1.53 to 21.77), or food and beverage services (OR = 4.36; 95% CI, 1.50 to 12.63) industries. There was little evidence of risk associated with maternal employment. Paternal employment before conception in jobs related particularly to metal or food and beverages may be related to testicular cancer risk in sons.
睾丸生殖细胞癌的发病率正在上升，但其病因在很大程度上仍不清楚。发病可能始于亲代生殖细胞。在安大略省的一项病例对照研究中，对343例病例受试者和524例对照受试者的母亲（怀孕前和怀孕期间）以及父亲（怀孕前）的工作和行业进行了分析。与木材加工工人（比值比[OR]=10.46；95%置信区间[CI]，1.20至91.14）、金属工人（OR=3.28；95%CI，1.03至10.52）、固定工程师（OR=1.05；95%CI，1.05至11.87）或食品行业（OR=2.79；95%CI，1.34至5.79）、金属制品行业（OR=5.77，95%CI，1.53至21.77）或食品和饮料服务业（OR=4.36；95%CI，1.50至12.63）的父亲相关的风险显著增加。几乎没有证据表明母亲的职业与风险有关。受孕前父亲从事与金属或食品和饮料特别相关的工作可能与儿子患睾丸癌的风险有关。
