钴胺素生物化学的阴阳学说
The Yin-Yang of cobalamin biochemistry.
作者信息
Banerjee R
机构信息
Biochemistry Department University of Nebraska Lincoln, NE 68588-0664, USA.
出版信息
Chem Biol. 1997 Mar;4(3):175-86. doi: 10.1016/s1074-5521(97)90286-6.
PMID:9115408
Abstract
The cobalamins are B12 cofactors with a reactive cobalt-carbon bond at their core and support the activity of two mammalian enzymes that are both medically important. The reactive organometallic bond of the cofactor can be cleaved either homolytically or heterolytically, but what determines how the enzymes control the fate of this bond?
摘要
钴胺素是核心具有活性钴-碳键的维生素B12辅因子，支持两种在医学上都很重要的哺乳动物酶的活性。辅因子的活性有机金属键可以通过均裂或异裂方式断裂，但是什么决定了这些酶如何控制该键的命运呢？
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