Shilatifard A, Conaway J W, Conaway R C
Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma, 73104, USA.
Curr Opin Genet Dev. 1997 Apr;7(2):199-204. doi: 10.1016/s0959-437x(97)80129-3.
Over the past year, key advances in several areas of research on the structure and function of the RNA polymerase (pol II) elongation complex have shed considerable light on the mechanisms governing the elongation stage of eukaryotic mRNA synthesis. Novel features of the regulation of elongation by DNA and RNA binding transcriptional activators have been brought to light; the mechanisms of action of elongation factors that suppress pausing and premature arrest by transcribing pol II have been defined in greater detail; and novel elongation factors implicated in human disease have been identified and characterized.
在过去的一年里，RNA聚合酶（pol II）延伸复合物结构与功能的几个研究领域取得了关键进展，为真核生物mRNA合成延伸阶段的调控机制提供了相当多的见解。DNA和RNA结合转录激活因子对延伸调控的新特点已被揭示；抑制转录pol II暂停和过早终止的延伸因子的作用机制已得到更详细的界定；与人类疾病相关的新型延伸因子也已被鉴定和表征。
