Reines D, Conaway R C, Conaway J W
Department of Biochemistry, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.
Curr Opin Cell Biol. 1999 Jun;11(3):342-6. doi: 10.1016/S0955-0674(99)80047-7.
Over the past few years, biochemical and genetic studies have shed considerable light on the structure and function of the RNA polymerase II (pol II) elongation complex and the transcription factors that control it. Novel elongation factors have been identified and their mechanisms of action characterized in increasing detail; new insights into the biological roles of elongation factors have been gained from genetic studies of the regulation of mRNA synthesis in yeast; and intriguing links between the pol II elongation machinery and the pathways of DNA repair and recombination have emerged.
在过去几年中,生化和遗传学研究为RNA聚合酶II(pol II)延伸复合物及其调控转录因子的结构与功能带来了相当多的启发。已鉴定出新型延伸因子,并对其作用机制进行了越来越详细的表征;通过对酵母中mRNA合成调控的遗传学研究,对延伸因子的生物学作用有了新的认识;并且,pol II延伸机制与DNA修复和重组途径之间也出现了有趣的联系。